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[Cancer Research 65, 2507-2510, April 1, 2005]
© 2005 American Association for Cancer Research

Reviews

A New Perspective on Tumor Endothelial Cells: Unexpected Chromosome and Centrosome Abnormalities

Kyoko Hida and Michael Klagsbrun

Vascular Biology Program and Departments of Surgery and Pathology, Children's Hospital and Harvard Medical School, Boston, Massachusetts

Requests for reprints: Michael Klagsbrun, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115. Phone: 617-919-2157; Fax: 617-730-0233; E-mail: michael.klagsbrun{at}childrens.harvard.edu.

It has been shown that endothelial cells in solid tumors are cytogenetically abnormal. These cells are aneuploid with multiple chromosomes and multiple centrosomes. Unlike normal endothelial cells which remain diploid in long-term culture, the aneuploidy of tumor endothelial cells is exacerbated in culture suggesting that these cells are inherently unstable. It is speculated that this instability might compromise the effectiveness of antiangiogenesis therapy.

Key Words: tumor endothelial cell




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Copyright © 2005 by the American Association for Cancer Research.