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Therapeutic Targeting of the Hedgehog-GLI Pathway in Prostate Cancer

Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland

Requests for reprints: Ariel Ruiz i Altaba, Department of Genetic Medicine and Development, University of Geneva Medical School, 8242 CMU, 1 rue Michel Servet, CH-1211 Geneva 4, Switzerland. Phone: 41-22-379-5646; Fax: 41-22-379-5962; E-mail: Ariel.RuizAltaba{at}medecine.unige.ch.

The Hedgehog-GLI signaling pathway is important in animal development and tumorigenesis. Recent findings indicate that the growth and survival of human prostate cancer cells rely upon sustained signaling from the Hedgehog-GLI pathway. These findings have prompted a novel rational strategy for therapeutic treatment of prostate tumors, including metastatic tumors.

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