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1 Department of Endocrinology and Metabolism, Orthopedic and Traumatology, Occupational Medicine, University of Pisa; 2 Pathologic Anatomy Service, S.Chiara Hospital, Pisa, Italy; 3 Pathology Unit, Department of Oncology, Azienda Sanitaria Ospedaliera, Alessandria, Italy; 4 National Cancer Research Institute, Unit of Environmental Epidemiology, Genoa, Italy; 5 Section of Histology and Embryology,Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy; 6 S.Pietro e Paolo Hospital, Borgosesia, Italy; and 7 S.Maugeri Foundation Institute for Research and Care, Pavia, Italy
Requests for reprints: Alfonso Cristaudo, Occupational Preventive Medicine, AOP, Via S.Maria 110, 56100 Pisa, Italy. Phone: 39-50993820; Fax: 39-50993822; E-mail: a.cristaudo{at}med.unipi.it.
We conducted a case-control study on asbestos exposure and presence of SV40 in tumor samples of malignant mesotheliomas (MMs) and bladder urotheliomas (BUs). PCR analysis revealed the presence of SV40 DNA (SV40+) in eight (42.1%) MMs and 6 (33.3%) BUs. The odds ratio for MM Asb– and SV40+ was 0.4 [95% confidence interval (95% CI), 0.03-4.0], for Asb+ and SV40– was 3.6 (95% CI, 0.6-21.0), and for Asb+ and SV40+ was 12.6 (95% CI, 1.2-133.9). Our results suggest that SV40 increases the risk of MM among individuals exposed to asbestos.
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