| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Reviews |
Gene Expression and Regulation Program, and Molecular and Cellular Oncogenesis Program, Wistar Institute, Philadelphia, Pennsylvania
Requests for reprints: Ramin Shiekhattar, Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104. Phone: 215-898-3896; Fax: 215-898-3868; E-mail: shiekhattar{at}wistar.upenn.edu.
MicroRNAs (miRNA) are a recently discovered family of short non–protein-coding RNAs that negatively regulate gene expression. Recent studies of miRNAs highlight a requirement for cell viability. Posttranscriptional silencing of target genes by miRNAs occurs either by targeting specific cleavage of homologous mRNAs, or by targeting specific inhibition of protein synthesis. We recently identified a multisubunit protein complex termed Microprocessor that is necessary and sufficient for processing miRNA precursor RNAs. Microprocessor contains Drosha, an RNase III endonuclease, and DGCR8, a gene deleted in DiGeorge syndrome. We consider recent findings that link miRNA perturbation to cancer.
This article has been cited by other articles:
|
|
 |
|
  M. Hackenberg and R. Matthiesen Annotation-Modules: a tool for finding significant combinations of multisource annotations for gene lists Bioinformatics, June 1, 2008; 24(11): 1386 - 1393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-W. Lee, C. H. Choi, J.-J. Choi, Y.-A. Park, S.-J. Kim, S. Y. Hwang, W. Y. Kim, T.-J. Kim, J.-H. Lee, B.-G. Kim, et al. Altered MicroRNA Expression in Cervical Carcinomas Clin. Cancer Res., May 1, 2008; 14(9): 2535 - 2542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. E. Blower, J.-H. Chung, J. S. Verducci, S. Lin, J.-K. Park, Z. Dai, C.-G. Liu, T. D. Schmittgen, W. C. Reinhold, C. M. Croce, et al. MicroRNAs modulate the chemosensitivity of tumor cells Mol. Cancer Ther., January 1, 2008; 7(1): 1 - 9. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. He, L. Zhu, N. Gupta, Y. Chang, and F. Fang Overexpression of Micro Ribonucleic Acid 29, Highly Up-Regulated in Diabetic Rats, Leads to Insulin Resistance in 3T3-L1 Adipocytes Mol. Endocrinol., November 1, 2007; 21(11): 2785 - 2794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Guan, W.-L. Kuo, J. L. Stilwell, H. Takano, A. V. Lapuk, J. Fridlyand, J.-H. Mao, M. Yu, M. A. Miller, J. L. Santos, et al. Amplification of PVT1 Contributes to the Pathophysiology of Ovarian and Breast Cancer Clin. Cancer Res., October 1, 2007; 13(19): 5745 - 5755. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Galardi, N. Mercatelli, E. Giorda, S. Massalini, G. V. Frajese, S. A. Ciafre, and M. G. Farace miR-221 and miR-222 Expression Affects the Proliferation Potential of Human Prostate Carcinoma Cell Lines by Targeting p27Kip1 J. Biol. Chem., August 10, 2007; 282(32): 23716 - 23724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sugito, H. Ishiguro, Y. Kuwabara, M. Kimura, A. Mitsui, H. Kurehara, T. Ando, R. Mori, N. Takashima, R. Ogawa, et al. RNASEN Regulates Cell Proliferation and Affects Survival in Esophageal Cancer Patients Clin. Cancer Res., December 15, 2006; 12(24): 7322 - 7328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Chiosea, E. Jelezcova, U. Chandran, M. Acquafondata, T. McHale, R. W. Sobol, and R. Dhir Up-Regulation of Dicer, a Component of the MicroRNA Machinery, in Prostate Adenocarcinoma Am. J. Pathol., November 1, 2006; 169(5): 1812 - 1820. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Zhang, J. Huang, N. Yang, J. Greshock, M. S. Megraw, A. Giannakakis, S. Liang, T. L. Naylor, A. Barchetti, M. R. Ward, et al. microRNAs exhibit high frequency genomic alterations in human cancer PNAS, June 13, 2006; 103(24): 9136 - 9141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P Pallante, R Visone, M Ferracin, A Ferraro, M T Berlingieri, G Troncone, G Chiappetta, C G Liu, M Santoro, M Negrini, et al. MicroRNA deregulation in human thyroid papillary carcinomas. Endocr. Relat. Cancer, June 1, 2006; 13(2): 497 - 508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ohrt, D. Merkle, K. Birkenfeld, C. J. Echeverri, and P. Schwille In situ fluorescence analysis demonstrates active siRNA exclusion from the nucleus by Exportin 5 Nucleic Acids Res., March 6, 2006; 34(5): 1369 - 1380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Shahi, S. Loukianiouk, A. Bohne-Lang, M. Kenzelmann, S. Kuffer, S. Maertens, R. Eils, H.-J. Grone, N. Gretz, and B. Brors Argonaute--a database for gene regulation by mammalian microRNAs Nucleic Acids Res., January 1, 2006; 34(suppl_1): D115 - D118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Cimmino, G. A. Calin, M. Fabbri, M. V. Iorio, M. Ferracin, M. Shimizu, S. E. Wojcik, R. I. Aqeilan, S. Zupo, M. Dono, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2 PNAS, September 27, 2005; 102(39): 13944 - 13949. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
