This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gutmann, D. H. Articles by Van Dyke, T. Search for Related Content PubMed PubMed Citation Articles by Gutmann, D. H. Articles by Van Dyke, T.

Mouse Models of Human Cancers Consortium Workshop on Nervous System Tumors

¹ Department of Neurology, Washington University School of Medicine, St. Louis, Missouri; ² Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and ³ Lineberger Comprehensive Cancer Center, Department of Genetics, University of North Carolina, Chapel Hill, North Carolina

Requests for reprints: David H. Gutmann, Department of Neurology, Washington University School of Medicine, Box 8111, 660 South Euclid Avenue, St. Louis, MO 63110. Phone: 314-362-7379; Fax: 314-362-2388; E-mail: gutmannd{at}neuro.wustl.edu.

Nervous system tumors are clinically challenging neoplasms that form within the central and peripheral nervous system. Although there have been many clinical trials using novel agents for the treatment of primary brain tumors, there have been few advances that positively affect overall patient survival. Over the past several years, there has been significant progress in the development of accurate small-animal spontaneous brain tumor models, small-animal neuroimaging, and tools for the bioinformatic analysis of complex molecular data sets, all of which have contributed to an improved understanding of the pathogenesis of human brain tumors. Whereas these models will continue to be of great value in basic science investigations, they can also be used to identify and validate potential therapies for brain tumors and to evaluate these drugs in preclinical trials. The National Cancer Institute recently convened a workshop to review the current state of small-animal brain tumor modeling and to make recommendations about the use of these models to improve the clinical outcome for patients with brain tumors. In this meeting report, we outline the current state of small-animal models for brain tumors, the potential applications of these models, and the recommendations made by the workshop participants for the use of mouse models in the preclinical evaluation of potential brain tumor therapies. (Cancer Res 2006; 66(1): 10-3)

This article has been cited by other articles:

				B. A Teicher Tumor Models for Efficacy Determination Am. Assoc. Cancer Res. Educ. Book, April 12, 2008; 2008(1): 571 - 585. [Abstract] [Full Text] [PDF]

				B. A. Teicher Tumor models for efficacy determination. Mol. Cancer Ther., October 1, 2006; 5(10): 2435 - 2443. [Abstract] [Full Text] [PDF]