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[Cancer Research 66, 2-5, January 1, 2006]
© 2006 American Association for Cancer Research

Reviews

EphB/EphrinB Receptors and Wnt Signaling in Colorectal Cancer

Hans Clevers1 and Eduard Batlle2

1 Hubrecht Laboratory and Centre for Biomedical Genetics, Utrecht, the Netherlands, and 2 Institució Catalana de Recerca i Estudis Avançats and Barcelona Science Park, Barcelona, Spain

Requests for reprints: Eduard Batlle, Barcelona Science Park, Josep Samitier 1-5, 08028 Barcelona, Spain. E-mail: ebatlle{at}pcb.ub.es.

Eph receptors and their ephrin ligands mediate cell repulsion during embryonic development. In the intestinal epithelium, EphB receptors are Wnt signaling target genes that control cell compartmentalization along the crypt axis. Recent findings have shown that this family of receptors are key players during colorectal cancer progression. Here, we review the current knowledge of the EphB/ephrinB system in the intestinal epithelium and we discuss their tumor suppressor role in the context of the multistep progression of colorectal cancer. (Cancer Res 2006; 66(1): 2-5)




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Copyright © 2006 by the American Association for Cancer Research.