Cancer Research CTRC-AACR San Antonio Breast Cancer Symposium Translational Medicine Conference in Israel
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Clevers, H.
Right arrow Articles by Batlle, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Clevers, H.
Right arrow Articles by Batlle, E.
Related Collections
Right arrow Cellular Pathobiology
Right arrow Cellular Pathobiology: Cancer Genes and Genomics
[Cancer Research 66, 2-5, January 1, 2006]
© 2006 American Association for Cancer Research

Reviews

EphB/EphrinB Receptors and Wnt Signaling in Colorectal Cancer

Hans Clevers1 and Eduard Batlle2

1 Hubrecht Laboratory and Centre for Biomedical Genetics, Utrecht, the Netherlands, and 2 Institució Catalana de Recerca i Estudis Avançats and Barcelona Science Park, Barcelona, Spain

Requests for reprints: Eduard Batlle, Barcelona Science Park, Josep Samitier 1-5, 08028 Barcelona, Spain. E-mail: ebatlle{at}pcb.ub.es.

Eph receptors and their ephrin ligands mediate cell repulsion during embryonic development. In the intestinal epithelium, EphB receptors are Wnt signaling target genes that control cell compartmentalization along the crypt axis. Recent findings have shown that this family of receptors are key players during colorectal cancer progression. Here, we review the current knowledge of the EphB/ephrinB system in the intestinal epithelium and we discuss their tumor suppressor role in the context of the multistep progression of colorectal cancer. (Cancer Res 2006; 66(1): 2-5)




This article has been cited by other articles:


Home page
 Hum Mol GenetHome page
E. M. Kohler, A. Derungs, G. Daum, J. Behrens, and J. Schneikert
Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours
Hum. Mol. Genet., July 1, 2008; 17(13): 1978 - 1987.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
M. Lackmann and A. W. Boyd
Eph, a Protein Family Coming of Age: More Confusion, Insight, or Complexity?
Sci. Signal., April 15, 2008; 1(15): re2 - re2.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
F. Boudreau, C. R. Lussier, S. Mongrain, M. Darsigny, J. L. Drouin, G. Doyon, E. R. Suh, J.-F. Beaulieu, N. Rivard, and N. Perreault
Loss of cathepsin L activity promotes claudin-1 overexpression and intestinal neoplasia
FASEB J, December 1, 2007; 21(14): 3853 - 3865.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
A. Kaidi, M. Moorghen, A. C. Williams, and C. Paraskeva
Is the downregulation of EphB2 receptor expression during colorectal tumorigenesis due to hypoxia?
Gut, November 1, 2007; 56(11): 1637 - 1638.
[Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J. M. Halbleib, A. M. Saaf, P. O. Brown, and W. J. Nelson
Transcriptional Modulation of Genes Encoding Structural Characteristics of Differentiating Enterocytes During Development of a Polarized Epithelium In Vitro
Mol. Biol. Cell, November 1, 2007; 18(11): 4261 - 4278.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
J. A. Crowell, V. E. Steele, and J. R. Fay
Targeting the AKT protein kinase for cancer chemoprevention
Mol. Cancer Ther., August 1, 2007; 6(8): 2139 - 2148.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. K. Noren and E. B. Pasquale
Paradoxes of the EphB4 Receptor in Cancer
Cancer Res., May 1, 2007; 67(9): 3994 - 3997.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
J. Schneikert and J. Behrens
The canonical Wnt signalling pathway and its APC partner in colon cancer development
Gut, March 1, 2007; 56(3): 417 - 425.
[Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. J. Pelham, L. Rodgers, I. Hall, R. Lucito, K. C. Q. Nguyen, N. Navin, J. Hicks, D. Mu, S. Powers, M. Wigler, et al.
Identification of alterations in DNA copy number in host stromal cells during tumor progression
PNAS, December 26, 2006; 103(52): 19848 - 19853.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
H. Liu, S. Thurig, O. Mohamed, D. Dufort, and V. A. Wallace
Mapping Canonical Wnt Signaling in the Developing and Adult Retina
Invest. Ophthalmol. Vis. Sci., November 1, 2006; 47(11): 5088 - 5097.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2006 by the American Association for Cancer Research.