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Pathology of Genetically Engineered Mouse Models of Pancreatic Exocrine Cancer: Consensus Report and Recommendations

Ralph H. Hruban^1,2, N. Volkan Adsay⁵, Jorge Albores-Saavedra⁶, Miriam R. Anver⁷, Andrew V. Biankin³, Gregory P. Boivin⁸, Emma E. Furth⁹, Toru Furukawa¹², Alison Klein^1,2, David S. Klimstra¹³, Gnter Klppel¹⁴, Gregory Y. Lauwers¹⁵, Daniel S. Longnecker¹⁷, Jutta Lttges¹⁸, Anirban Maitra^1,2,4, G. Johan A. Offerhaus¹⁹, Lucía Pérez-Gallego²⁰, Mark Redston¹⁶ and David A. Tuveson^10,11

Departments of ¹ Pathology, ² Oncology, and ³ Surgery and ⁴ the Institute for Genetic Medicine, The Sol Goldman Center for Pancreatic Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland; ⁵ Department of Pathology, Wayne State University, Harper Hospital, Detroit, Michigan; ⁶ Department of Pathology, Louisiana State University, Shreveport, Louisiana; ⁷ Pathology/Histochemistry Laboratory, SAIC Frederick, Inc., Frederick, Maryland; ⁸ Department of Pathology, The University of Cincinnati, Cincinnati, Ohio; Departments of ⁹ Pathology, ¹⁰ Medicine, and ¹¹ Cancer Biology, Abramson Family Cancer Research Institute, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania; ¹² International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women's Medical University, Tokyo, Japan; ¹³ Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York; ¹⁴ Department of Pathology, University of Kiel, Kiel, Germany; ¹⁵ Department of Pathology, Massachusetts General Hospital; ¹⁶ Department of Pathology, Brigham and Woman's Hospital, Boston, Massachusetts; ¹⁷ Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hamsphire; ¹⁸ Department of Pathology, Teaching Hospital University Homburg, Saarbrücken, Germany; ¹⁹ Department of Pathology, The Academic Medical Center, Amsterdam, the Netherlands; and ²⁰ Comparative Pathology, Spanish National Cancer Centre, Madrid, Spain

Requests for reprints: Ralph H. Hruban, The Sol Goldman Pancreatic Cancer Center, The Johns Hopkins Hospital, 401 North Broadway, Weinberg 2242, Baltimore, MD 21231. Phone: 410-955-9132; Fax: 410-955-0115; E-mail: rhruban{at}jhmi.edu.

Several diverse genetically engineered mouse models of pancreatic exocrine neoplasia have been developed. These mouse models have a spectrum of pathologic changes; however, until now, there has been no uniform nomenclature to characterize these changes. An international workshop, sponsored by The National Cancer Institute and the University of Pennsylvania, was held from December 1 to 3, 2004 with the goal of establishing an internationally accepted uniform nomenclature for the pathology of genetically engineered mouse models of pancreatic exocrine neoplasia. The pancreatic pathology in 12 existing mouse models of pancreatic neoplasia was reviewed at this workshop, and a standardized nomenclature with definitions and associated images was developed. It is our intention that this nomenclature will standardize the reporting of genetically engineered mouse models of pancreatic exocrine neoplasia, that it will facilitate comparisons between genetically engineered mouse models and human pancreatic disease, and that it will be broad enough to accommodate newly emerging mouse models of pancreatic neoplasia. (Cancer Res 2006; 66(1): 95-106)

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