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[Cancer Research 66, 5977-5980, June 15, 2006]
© 2006 American Association for Cancer Research

Reviews

Fatty Acid Synthase and Cancer: New Application of an Old Pathway

Francis P. Kuhajda

Departments of Pathology, Oncology, and Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland

Requests for reprints: Francis P. Kuhajda, Department of Pathology, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224. Phone: 410-550-0671; Fax: 410-550-0075; E-mail: fkuhajda{at}jhmi.edu.

Fatty acid synthase (FAS), the sole mammalian enzyme capable of de novo fatty acid synthesis, is highly expressed in most human carcinomas. FAS is associated with poor prognosis in breast and prostate cancer, is elaborated into the blood of cancer patients, and its inhibition is selectively cytotoxic to human cancer cells. Thus, FAS and fatty acid metabolism in cancer has become a focus for the potential diagnosis and treatment of cancer. (Cancer Res 2006; 66(12): 5977-80)




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