This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Müller-Berghaus, J. Articles by Schadendorf, D. Search for Related Content PubMed PubMed Citation Articles by Müller-Berghaus, J. Articles by Schadendorf, D.

Melanoma-Reactive T Cells in the Bone Marrow of Melanoma Patients: Association with Disease Stage and Disease Duration

¹ Skin Cancer Unit, German Cancer Research Center Heidelberg and University Hospital Mannheim, Mannheim, Germany and ² Division of Cellular Immunology, German Cancer Research Center Heidelberg, Heidelberg, Germany

Requests for reprints: Philipp Beckhove or Dirk Schadendorf, Deutsches Krebsforschungszentrum, Abteilung für zelluläre Immunologie, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Phone: 49-6221-42-3743; Fax 49-6221-42-3702; E-mail: p.beckhove{at}dkfz.de or d.schadendorf{at}dkfz.de.

Using IFN- enzyme-linked immunospot, we investigated reactivity of T cells from bone marrow and peripheral blood to melanoma lysate-pulsed autologous dendritic cells in 40 melanoma patients. Melanoma-reactive T cells were present in the bone marrow of seven patients and in peripheral blood of four patients. In the bone marrow, melanoma-reactive T cells were present in 6 of 21 stage IV patients and in 1 of 10 stage III patients, whereas none were detected in stage I to II patients (0 of 9). The occurrence of tumor-reactive bone marrow T cells in melanoma patients was associated with advanced disease stage, disease duration and tumor load, and independent of treatment. These findings provide new insights into the generation of T-cell responses in melanoma patients. (Cancer Res 2006; 66(12): 5997-6001)

This article has been cited by other articles:

				C. Domschke, F. Schuetz, Y. Ge, T. Seibel, C. Falk, B. Brors, I. Vlodavsky, N. Sommerfeldt, H.-P. Sinn, M.-C. Kuhnle, et al. Intratumoral Cytokines and Tumor Cell Biology Determine Spontaneous Breast Cancer-Specific Immune Responses and Their Correlation to Prognosis Cancer Res., November 1, 2009; 69(21): 8420 - 8428. [Abstract] [Full Text] [PDF]

				B. C. Trainor, C. Sweeney, and R. Cardiff Isolating the Effects of Social Interactions on Cancer Biology Cancer Prevention Research, October 1, 2009; 2(10): 843 - 846. [Abstract] [Full Text] [PDF]

				J. J. Melenhorst, P. Scheinberg, P. K. Chattopadhyay, E. Gostick, K. Ladell, M. Roederer, N. F. Hensel, D. C. Douek, A. J. Barrett, and D. A. Price High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrow Blood, March 5, 2009; 113(10): 2238 - 2244. [Abstract] [Full Text] [PDF]

				V. Umansky, O. Abschuetz, W. Osen, M. Ramacher, F. Zhao, M. Kato, and D. Schadendorf Melanoma-Specific Memory T Cells Are Functionally Active in Ret Transgenic Mice without Macroscopic Tumors Cancer Res., November 15, 2008; 68(22): 9451 - 9458. [Abstract] [Full Text] [PDF]