This Article Full Text Full Text (PDF) Supplementary Data Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kudo, Y. Articles by Takata, T. Search for Related Content PubMed PubMed Citation Articles by Kudo, Y. Articles by Takata, T.

Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer

¹ Department of Oral Maxillofacial Pathobiology, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, ² Center of Oral Clinical Examination, Hiroshima University Hospital, ³ Department of Regulatory Radiobiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan; and ⁴ Division of Hematology, Oncology and Transplantation, Institute of Human Genetics, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota

Requests for reprints: Yasusei Kudo or Takashi Takata, Department of Oral Maxillofacial Pathobiology, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. Phone: 81-82-257-5634; Fax: 81-82-257-5619; E-mail: ykudo{at}hiroshima-u.ac.jp or ttakata@hiroshima-u.ac.jp.

Head and neck squamous cell carcinoma (HNSCC) is one of the most common types of human cancer. Typically, HNSCC cells show persistent invasion that frequently leads to local recurrence and distant lymphatic metastasis. However, molecular mechanisms associated with the invasion and metastasis of HNSCC remain poorly understood. Here, we identified periostin as an invasion-promoting factor in HNSCC by comparing the gene expression profiles between parent HNSCC cells and a highly invasive clone. Indeed, periostin overexpression promoted invasion and anchorage-independent growth both in vitro and in vivo in HNSCC cells. Moreover, periostin-overexpressing cells spontaneously metastasized to cervical lymph nodes and to the lung through their aggressive invasiveness in an orthotopic mouse model of HNSCC. Interestingly, periostin was highly expressed in HNSCCs in comparison with normal tissues, and the level of periostin expression was well correlated with the invasiveness of HNSCC cases. In summary, these findings suggest that periostin plays an important role in the invasion and anchorage-independent growth of HNSCC. (Cancer Res 2006; 66(14): 6928-35)

This article has been cited by other articles:

				S. Rani, M. F. Barbe, A. E. Barr, and J. Litvin Induction of Periostin-like Factor and Periostin in Forearm Muscle, Tendon, and Nerve in an Animal Model of Work-related Musculoskeletal Disorder J. Histochem. Cytochem., November 1, 2009; 57(11): 1061 - 1073. [Abstract] [Full Text] [PDF]

				C.-C. Huang, S. Gadd, N. Breslow, C. Cutcliffe, S. T. Sredni, I. B. Helenowski, J. S. Dome, P. E. Grundy, D. M. Green, M. K. Fritsch, et al. Predicting Relapse in Favorable Histology Wilms Tumor Using Gene Expression Analysis: A Report from the Renal Tumor Committee of the Children's Oncology Group Clin. Cancer Res., March 1, 2009; 15(5): 1770 - 1778. [Abstract] [Full Text] [PDF]

				A. Soltermann, V. Tischler, S. Arbogast, J. Braun, N. Probst-Hensch, W. Weder, H. Moch, and G. Kristiansen Prognostic Significance of Epithelial-Mesenchymal and Mesenchymal-Epithelial Transition Protein Expression in Non-Small Cell Lung Cancer Clin. Cancer Res., November 15, 2008; 14(22): 7430 - 7437. [Abstract] [Full Text] [PDF]

				B. Quaresima, F. Romeo, M. C. Faniello, M. Di Sanzo, C.-G. Liu, A. Lavecchia, C. Taccioli, E. Gaudio, F. Baudi, F. Trapasso, et al. BRCA1 5083del19 Mutant Allele Selectively Up-Regulates Periostin Expression In vitro and In vivo Clin. Cancer Res., November 1, 2008; 14(21): 6797 - 6803. [Abstract] [Full Text] [PDF]

				H. Hatano, Y. Kudo, I. Ogawa, T. Tsunematsu, A. Kikuchi, Y. Abiko, and T. Takata IFN-Induced Transmembrane Protein 1 Promotes Invasion at Early Stage of Head and Neck Cancer Progression Clin. Cancer Res., October 1, 2008; 14(19): 6097 - 6105. [Abstract] [Full Text] [PDF]

				Y. Kikuchi, T. G. Kashima, T. Nishiyama, K. Shimazu, Y. Morishita, M. Shimazaki, I. Kii, H. Horie, H. Nagai, A. Kudo, et al. Periostin Is Expressed in Pericryptal Fibroblasts and Cancer-associated Fibroblasts in the Colon J. Histochem. Cytochem., August 1, 2008; 56(8): 753 - 764. [Abstract] [Full Text] [PDF]

				P. Choi, C. D. Jordan, E. Mendez, J. Houck, B. Yueh, D. G. Farwell, N. Futran, and C. Chen Examination of Oral Cancer Biomarkers by Tissue Microarray Analysis Arch Otolaryngol Head Neck Surg, May 1, 2008; 134(5): 539 - 546. [Abstract] [Full Text] [PDF]

				F Puglisi, C Puppin, E Pegolo, C Andreetta, G Pascoletti, F D'Aurizio, M Pandolfi, G Fasola, A Piga, G Damante, et al. Expression of periostin in human breast cancer J. Clin. Pathol., April 1, 2008; 61(4): 494 - 498. [Abstract] [Full Text] [PDF]