Cancer Research CTRC-AACR San Antonio Breast Cancer Symposium Cancer Health Disparities Conference 2009
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ramiro, A. R.
Right arrow Articles by Nussenzweig, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ramiro, A. R.
Right arrow Articles by Nussenzweig, A.
Related Collections
Right arrow Cellular Pathobiology
Right arrow Cellular Pathobiology: Cancer Genes and Genomics
[Cancer Research 66, 7837-7839, August 15, 2006]
© 2006 American Association for Cancer Research

Reviews

Switching on Chromosomal Translocations

Almudena R. Ramiro1, Michel C. Nussenzweig2,3 and André Nussenzweig4

1 DNA Hypermutation Group, Spanish National Cancer Center, Madrid, Spain; 2 Laboratory of Molecular Immunology, The Rockefeller University; 3 Howard Hughes Medical Institute, New York, New York; and 4 Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, Maryland

Requests for reprints: Almudena R. Ramiro, DNA Hypermutation Group, Spanish National Cancer Center, Madrid 28029, Spain. Phone: 34-91-732-8055; Fax: 34-917-8033; E-mail: arodriguezr{at}cnio.es.

Activation-induced deaminase initiates three different antibody diversification reactions: class switch recombination, somatic hypermutation (SHM), and gene conversion. We have shown that, in addition to antibody diversification, activation-induced deaminase can also initiate Burkitt's lymphoma–like c-myc/IgH translocations. However, distinct DNA damage- and oncogene-induced checkpoints operate in B cells to produce a normal intrachromosomal class switch recombination event or an aberrant interchromosomal fusion. These findings open the way to study the molecular pathways taking place at the early stages of malignant transformation. (Cancer Res 2006; 66(16): 7837-9)




This article has been cited by other articles:


Home page
 J. Exp. Med.Home page
A. L. Kovalchuk, W. duBois, E. Mushinski, N. E. McNeil, C. Hirt, C.-F. Qi, Z. Li, S. Janz, T. Honjo, M. Muramatsu, et al.
AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements
J. Exp. Med., November 26, 2007; 204(12): 2989 - 3001.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. L. Duquette, M. D. Huber, and N. Maizels
G-Rich Proto-Oncogenes Are Targeted for Genomic Instability in B-Cell Lymphomas
Cancer Res., March 15, 2007; 67(6): 2586 - 2594.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
D. Ronai, M. D. Iglesias-Ussel, M. Fan, Z. Li, A. Martin, and M. D. Scharff
Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation
J. Exp. Med., January 22, 2007; 204(1): 181 - 190.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2006 by the American Association for Cancer Research.