This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Amend, K. Articles by Ambrosone, C. B. Search for Related Content PubMed PubMed Citation Articles by Amend, K. Articles by Ambrosone, C. B. Related Collections Epidemiology and Prevention Epidemiology and Prevention: Genetics and Biomarkers

Breast Cancer in African-American Women: Differences in Tumor Biology from European-American Women

¹ Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York and Departments of ² Pathology and ³ Epidemiology, Roswell Park Cancer Institute, Buffalo, New York

Requests for reprints: Christine B. Ambrosone, Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263. Phone: 716-845-3082; Fax: 716-845-8125; E-mail: Christine.ambrosone{at}roswellpark.org.

Disparities exist between African-American and European-American women in the incidence and nature of breast cancer. African-American women are more often diagnosed with breast cancer at an earlier age and with more aggressive disease, characterized by higher grade and negative estrogen and progesterone receptor status. Recent findings reveal specific gene expression patterns associated with the more aggressive breast cancers observed in African-American women. An overview of the current literature about racial differences in breast cancer prompts questions for future research to elucidate causes for the apparent disparities in tumor biology. (Cancer Res 2006; 66(17): 8327-30)

This article has been cited by other articles:

				E. Caldas-Lopes, L. Cerchietti, J. H. Ahn, C. C. Clement, A. I. Robles, A. Rodina, K. Moulick, T. Taldone, A. Gozman, Y. Guo, et al. Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models PNAS, May 19, 2009; 106(20): 8368 - 8373. [Abstract] [Full Text] [PDF]

				V. W. Setiawan, K. R. Monroe, L. R. Wilkens, L. N. Kolonel, M. C. Pike, and B. E. Henderson Breast Cancer Risk Factors Defined by Estrogen and Progesterone Receptor Status: The Multiethnic Cohort Study Am. J. Epidemiol., May 15, 2009; 169(10): 1251 - 1259. [Abstract] [Full Text] [PDF]