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[Cancer Research 66, 8927-8930, September 15, 2006]
© 2006 American Association for Cancer Research

Reviews

Cancer's Molecular Sweet Tooth and the Warburg Effect

Jung-whan Kim1 and Chi V. Dang1,2

1 Division of Hematology, Department of Medicine, 2 The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland

Requests for reprints: Chi V. Dang, Ross Research Building, Room 1032, 720 Rutland Avenue, Baltimore, MD 21205. Phone: 410-955-2773; Fax: 410-955-0185; E-mail: cvdang{at}jhmi.edu.

More than 80 years ago, the renowned biochemist Otto Warburg described how cancer cells avidly consume glucose and produce lactic acid under aerobic conditions. Recent studies arguing that cancer cells benefit from this phenomenon, termed the Warburg effect, have renewed discussions about its exact role as cause, correlate, or facilitator of cancer. Molecular advances in this area may reveal tactics to exploit the cancer cell's "sweet tooth" for cancer therapy. (Cancer Res 2006; 66(18): 8927-30)




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