Cancer Research Annual Meeting 2010 Telomeres
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Huang, B.
Right arrow Articles by Chen, S.-H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Huang, B.
Right arrow Articles by Chen, S.-H.
[Cancer Research 66, 1123-1131, January 15, 2006]
© 2006 American Association for Cancer Research

Immunology

Gr-1+CD115+ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host

Bo Huang1, Ping-Ying Pan1, Qingsheng Li1, Alice I. Sato1, David E. Levy3, Jonathan Bromberg1, Celia M. Divino2 and Shu-Hsia Chen1

Departments of 1 Gene and Cell Medicine and 2 General Surgery, Mount Sinai School of Medicine; 3 Departments of Pathology and Microbiology, New York University School of Medicine, New York, New York

Requests for reprints: Shu-Hsia Chen, Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Box 1496, One Gustave L. Levy Place, New York, NY 10029. Phone: 212-659-8256; Fax: 212-803-6740; E-mail: shu-hsia.chen{at}mssm.edu.

The accumulation of myeloid suppressor cells (MSCs) is associated with immune suppression in tumor-bearing mice and in cancer patients. The suppressive activity of MSC correlates with the expression of the myeloid markers Gr-1, CD115 (macrophage colony-stimulating factor receptor), and F4/80. Gr-1+CD115+ MSCs, in addition to being able to suppress T-cell proliferation in vitro, can induce the development of Foxp3+ T regulatory cells (Treg) in vivo, which are anergic and suppressive. Furthermore, the secretion of interleukin (IL)-10 and transforming growth factor-ß by Gr-1+CD115+ MSCs was induced and enhanced, respectively, on IFN-{gamma} stimulation. The development of Treg requires antigen-associated activation of tumor-specific T cells, depends on the presence of IFN-{gamma} and IL-10, and is independent of the nitric oxide–mediated suppressive mechanism by MSC. Our data provide evidence that Gr-1+CD115+ MSC can mediate the development of Treg in tumor-bearing mice and show a novel immune suppressive mechanism by which MSCs can suppress antitumor responses. (Cancer Res 2006; 66(2): 1123-31)




This article has been cited by other articles:


Home page
 J. Immunol.Home page
M. Gil, M. Bieniasz, A. Wierzbicki, B. J. Bambach, H. Rokita, and D. Kozbor
Targeting a Mimotope Vaccine to Activating Fc{gamma} Receptors Empowers Dendritic Cells to Prime Specific CD8+ T Cell Responses in Tumor-Bearing Mice
J. Immunol., November 15, 2009; 183(10): 6808 - 6818.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
S. Y. Lim, M. J. Raftery, J. Goyette, K. Hsu, and C. L. Geczy
Oxidative modifications of S100 proteins: functional regulation by redox
J. Leukoc. Biol., September 1, 2009; 86(3): 577 - 587.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
K. C. McKenna, K. M. Beatty, R. A. Bilonick, L. Schoenfield, K. L. Lathrop, and A. D. Singh
Activated CD11b+ CD15+ Granulocytes Increase in the Blood of Patients with Uveal Melanoma
Invest. Ophthalmol. Vis. Sci., September 1, 2009; 50(9): 4295 - 4303.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. J. E. Raveney, D. A. Copland, A. D. Dick, and L. B. Nicholson
TNFR1-Dependent Regulation of Myeloid Cell Function in Experimental Autoimmune Uveoretinitis
J. Immunol., August 15, 2009; 183(4): 2321 - 2329.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. B. Olkhanud, D. Baatar, M. Bodogai, F. Hakim, R. Gress, R. L. Anderson, J. Deng, M. Xu, S. Briest, and A. Biragyn
Breast Cancer Lung Metastasis Requires Expression of Chemokine Receptor CCR4 and Regulatory T Cells
Cancer Res., July 15, 2009; 69(14): 5996 - 6004.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
F. Colotta, P. Allavena, A. Sica, C. Garlanda, and A. Mantovani
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
Carcinogenesis, July 1, 2009; 30(7): 1073 - 1081.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Ilkovitch and D. M. Lopez
The Liver Is a Site for Tumor-Induced Myeloid-Derived Suppressor Cell Accumulation and Immunosuppression
Cancer Res., July 1, 2009; 69(13): 5514 - 5521.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Ilkovitch and D. M. Lopez
Urokinase-mediated recruitment of myeloid-derived suppressor cells and their suppressive mechanisms are blocked by MUC1/sec
Blood, May 7, 2009; 113(19): 4729 - 4739.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Ostrand-Rosenberg and P. Sinha
Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer
J. Immunol., April 15, 2009; 182(8): 4499 - 4506.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. Hagemann, S. K. Biswas, T. Lawrence, A. Sica, and C. E. Lewis
Regulation of macrophage function in tumors: the multifaceted role of NF-{kappa}B
Blood, April 2, 2009; 113(14): 3139 - 3146.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. M. Collazo, D. Wood, K. H. T. Paraiso, E. Lund, R. W. Engelman, C.-T. Le, D. Stauch, K. Kotsch, and W. G. Kerr
SHIP limits immunoregulatory capacity in the T-cell compartment
Blood, March 26, 2009; 113(13): 2934 - 2944.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Zhang, Q. Liu, M. Zhang, Y. Yu, X. Liu, and X. Cao
Fas Signal Promotes Lung Cancer Growth by Recruiting Myeloid-Derived Suppressor Cells via Cancer Cell-Derived PGE2
J. Immunol., March 15, 2009; 182(6): 3801 - 3808.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Ozao-Choy, G. Ma, J. Kao, G. X. Wang, M. Meseck, M. Sung, M. Schwartz, C. M. Divino, P.-Y. Pan, and S.-H. Chen
The Novel Role of Tyrosine Kinase Inhibitor in the Reversal of Immune Suppression and Modulation of Tumor Microenvironment for Immune-Based Cancer Therapies
Cancer Res., March 15, 2009; 69(6): 2514 - 2522.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. S. Ko, A. H. Zea, B. I. Rini, J. L. Ireland, P. Elson, P. Cohen, A. Golshayan, P. A. Rayman, L. Wood, J. Garcia, et al.
Sunitinib Mediates Reversal of Myeloid-Derived Suppressor Cell Accumulation in Renal Cell Carcinoma Patients
Clin. Cancer Res., March 15, 2009; 15(6): 2148 - 2157.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H.-J. Ko, J.-M. Lee, Y.-J. Kim, Y.-S. Kim, K.-A Lee, and C.-Y. Kang
Immunosuppressive Myeloid-Derived Suppressor Cells Can Be Converted into Immunogenic APCs with the Help of Activated NKT Cells: An Alternative Cell-Based Antitumor Vaccine
J. Immunol., February 15, 2009; 182(4): 1818 - 1828.
[Abstract] [Full Text] [PDF]

Home page
 Anticancer ResHome page
F. RECCHIA, G. CANDELORO, S. NECOZIONE, R. BISEGNA, M. BRATTA, and S. REA
Immunotherapy in Patients with Less than Complete Response to Chemotherapy
Anticancer Res, February 1, 2009; 29(2): 567 - 572.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Kusmartsev, Z. Su, A. Heiser, J. Dannull, E. Eruslanov, H. Kubler, D. Yancey, P. Dahm, and J. Vieweg
Reversal of Myeloid Cell-Mediated Immunosuppression in Patients with Metastatic Renal Cell Carcinoma
Clin. Cancer Res., December 15, 2008; 14(24): 8270 - 8278.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N. Nausch, I. E. Galani, E. Schlecker, and A. Cerwenka
Mononuclear myeloid-derived "suppressor" cells express RAE-1 and activate natural killer cells
Blood, November 15, 2008; 112(10): 4080 - 4089.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. Koyama, H. Kagamu, S. Miura, T. Hiura, T. Miyabayashi, R. Itoh, H. Kuriyama, H. Tanaka, J. Tanaka, H. Yoshizawa, et al.
Reciprocal CD4+ T-Cell Balance of Effector CD62Llow CD4+ and CD62LhighCD25+ CD4+ Regulatory T Cells in Small Cell Lung Cancer Reflects Disease Stage
Clin. Cancer Res., November 1, 2008; 14(21): 6770 - 6779.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J.-I. Youn, S. Nagaraj, M. Collazo, and D. I. Gabrilovich
Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice
J. Immunol., October 15, 2008; 181(8): 5791 - 5802.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. H. Finke, B. Rini, J. Ireland, P. Rayman, A. Richmond, A. Golshayan, L. Wood, P. Elson, J. Garcia, R. Dreicer, et al.
Sunitinib Reverses Type-1 Immune Suppression and Decreases T-Regulatory Cells in Renal Cell Carcinoma Patients
Clin. Cancer Res., October 15, 2008; 14(20): 6674 - 6682.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Sinha, C. Okoro, D. Foell, H. H. Freeze, S. Ostrand-Rosenberg, and G. Srikrishna
Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells
J. Immunol., October 1, 2008; 181(7): 4666 - 4675.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
H. Song, K. Shahverdi, D. L. Huso, Y. Wang, J. J. Fox, R. F. Hobbs, B. Gimi, K. L. Gabrielson, M. G. Pomper, B. M. Tsui, et al.
An Immunotolerant HER-2/neu Transgenic Mouse Model of Metastatic Breast Cancer
Clin. Cancer Res., October 1, 2008; 14(19): 6116 - 6124.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
P. Cheng, C. A. Corzo, N. Luetteke, B. Yu, S. Nagaraj, M. M. Bui, M. Ortiz, W. Nacken, C. Sorg, T. Vogl, et al.
Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein
J. Exp. Med., September 29, 2008; 205(10): 2235 - 2249.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
J. W. Pollard
Macrophages define the invasive microenvironment in breast cancer
J. Leukoc. Biol., September 1, 2008; 84(3): 623 - 630.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Watanabe, K. Deguchi, R. Zheng, H. Tamai, L.-x. Wang, P. A. Cohen, and S. Shu
Tumor-Induced CD11b+Gr-1+ Myeloid Cells Suppress T Cell Sensitization in Tumor-Draining Lymph Nodes
J. Immunol., September 1, 2008; 181(5): 3291 - 3300.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. Muthuswamy, J. Urban, J.-J. Lee, T. A. Reinhart, D. Bartlett, and P. Kalinski
Ability of Mature Dendritic Cells to Interact with Regulatory T Cells Is Imprinted during Maturation
Cancer Res., July 15, 2008; 68(14): 5972 - 5978.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. J. Gough, C. E. Ruby, W. L. Redmond, B. Dhungel, A. Brown, and A. D. Weinberg
OX40 Agonist Therapy Enhances CD8 Infiltration and Decreases Immune Suppression in the Tumor
Cancer Res., July 1, 2008; 68(13): 5206 - 5215.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. Serafini, S. Mgebroff, K. Noonan, and I. Borrello
Myeloid-Derived Suppressor Cells Promote Cross-Tolerance in B-Cell Lymphoma by Expanding Regulatory T Cells
Cancer Res., July 1, 2008; 68(13): 5439 - 5449.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Kusmartsev, E. Eruslanov, H. Kubler, T. Tseng, Y. Sakai, Z. Su, S. Kaliberov, A. Heiser, C. Rosser, P. Dahm, et al.
Oxidative Stress Regulates Expression of VEGFR1 in Myeloid Cells: Link to Tumor-Induced Immune Suppression in Renal Cell Carcinoma
J. Immunol., July 1, 2008; 181(1): 346 - 353.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. Kobayashi, T. Yoshida, D. Takeuchi, V. C. Jones, K. Shigematsu, D. N. Herndon, and F. Suzuki
Gr-1+CD11b+ cells as an accelerator of sepsis stemming from Pseudomonas aeruginosa wound infection in thermally injured mice
J. Leukoc. Biol., June 1, 2008; 83(6): 1354 - 1362.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Cao, J. Zhao, Z. Lei, S. Shen, C. Liu, D. Li, J. Liu, G.-X. Shen, G.-M. Zhang, Z.-H. Feng, et al.
Local Accumulation of FOXP3+ Regulatory T Cells: Evidence for an Immune Evasion Mechanism in Patients with Large Condylomata Acuminata
J. Immunol., June 1, 2008; 180(11): 7681 - 7686.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Nagaraj and D. I. Gabrilovich
Tumor Escape Mechanism Governed by Myeloid-Derived Suppressor Cells
Cancer Res., April 15, 2008; 68(8): 2561 - 2563.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. Movahedi, M. Guilliams, J. Van den Bossche, R. Van den Bergh, C. Gysemans, A. Beschin, P. De Baetselier, and J. A. Van Ginderachter
Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity
Blood, April 15, 2008; 111(8): 4233 - 4244.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
I. Vaknin, L. Blinder, L. Wang, R. Gazit, E. Shapira, O. Genina, M. Pines, E. Pikarsky, and M. Baniyash
A common pathway mediated through Toll-like receptors leads to T- and natural killer-cell immunosuppression
Blood, February 1, 2008; 111(3): 1437 - 1447.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
P.-Y. Pan, G. X. Wang, B. Yin, J. Ozao, T. Ku, C. M. Divino, and S.-H. Chen
Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function
Blood, January 1, 2008; 111(1): 219 - 228.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. Kiniwa, Y. Miyahara, H. Y. Wang, W. Peng, G. Peng, T. M. Wheeler, T. C. Thompson, L. J. Old, and R.-F. Wang
CD8+ Foxp3+ Regulatory T Cells Mediate Immunosuppression in Prostate Cancer
Clin. Cancer Res., December 1, 2007; 13(23): 6947 - 6958.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Marhaba, M. Vitacolonna, D. Hildebrand, M. Baniyash, P. Freyschmidt-Paul, and M. Zoller
The Importance of Myeloid-Derived Suppressor Cells in the Regulation of Autoimmune Effector Cells by a Chronic Contact Eczema
J. Immunol., October 15, 2007; 179(8): 5071 - 5081.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Zhu, Y. Bando, S. Xiao, K. Yang, A. C. Anderson, V. K. Kuchroo, and S. J. Khoury
CD11b+Ly-6Chi Suppressive Monocytes in Experimental Autoimmune Encephalomyelitis
J. Immunol., October 15, 2007; 179(8): 5228 - 5237.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
P. Filipazzi, C. Castelli, V. Roberta, V. Huber, M. Iero, L. Pilla, L. Rivoltini, and G. Parmiani
In Reply
J. Clin. Oncol., October 10, 2007; 25(29): 4696 - 4697.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. E. Talmadge
Pathways Mediating the Expansion and Immunosuppressive Activity of Myeloid-Derived Suppressor Cells and Their Relevance to Cancer Therapy
Clin. Cancer Res., September 15, 2007; 13(18): 5243 - 5248.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H.-J. Ko, Y.-J. Kim, Y.-S. Kim, W.-S. Chang, S.-Y. Ko, S.-Y. Chang, S. Sakaguchi, and C.-Y. Kang
A Combination of Chemoimmunotherapies Can Efficiently Break Self-Tolerance and Induce Antitumor Immunity in a Tolerogenic Murine Tumor Model
Cancer Res., August 1, 2007; 67(15): 7477 - 7486.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Sinha, V. K. Clements, S. K. Bunt, S. M. Albelda, and S. Ostrand-Rosenberg
Cross-Talk between Myeloid-Derived Suppressor Cells and Macrophages Subverts Tumor Immunity toward a Type 2 Response
J. Immunol., July 15, 2007; 179(2): 977 - 983.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. G. Elpek, C. Lacelle, N. P. Singh, E. S. Yolcu, and H. Shirwan
CD4+CD25+ T Regulatory Cells Dominate Multiple Immune Evasion Mechanisms in Early but Not Late Phases of Tumor Development in a B Cell Lymphoma Model
J. Immunol., June 1, 2007; 178(11): 6840 - 6848.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Yu, C. Liu, K. Su, J. Wang, Y. Liu, L. Zhang, C. Li, Y. Cong, R. Kimberly, W. E. Grizzle, et al.
Tumor Exosomes Inhibit Differentiation of Bone Marrow Dendritic Cells
J. Immunol., June 1, 2007; 178(11): 6867 - 6875.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Liu, S. Yu, J. Kappes, J. Wang, W. E. Grizzle, K. R. Zinn, and H.-G. Zhang
Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host
Blood, May 15, 2007; 109(10): 4336 - 4342.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. Huang, J. Zhao, S. Shen, H. Li, K.-L. He, G.-X. Shen, L. Mayer, J. Unkeless, D. Li, Y. Yuan, et al.
Listeria monocytogenes Promotes Tumor Growth via Tumor Cell Toll-Like Receptor 2 Signaling
Cancer Res., May 1, 2007; 67(9): 4346 - 4352.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. Sinha, V. K. Clements, A. M. Fulton, and S. Ostrand-Rosenberg
Prostaglandin E2 Promotes Tumor Progression by Inducing Myeloid-Derived Suppressor Cells
Cancer Res., May 1, 2007; 67(9): 4507 - 4513.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. Vieweg, Z. Su, P. Dahm, and S. Kusmartsev
Reversal of Tumor-Mediated Immunosuppression
Clin. Cancer Res., January 15, 2007; 13(2): 727s - 732s.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. I. Gabrilovich, V. Bronte, S.-H. Chen, M. P. Colombo, A. Ochoa, S. Ostrand-Rosenberg, and H. Schreiber
The Terminology Issue for Myeloid-Derived Suppressor Cells
Cancer Res., January 1, 2007; 67(1): 425 - 425.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
E. Ambrosino, M. Spadaro, M. Iezzi, C. Curcio, G. Forni, P. Musiani, W.-Z. Wei, and F. Cavallo
Immunosurveillance of erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance.
Cancer Res., August 1, 2006; 66(15): 7734 - 7740.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2006 by the American Association for Cancer Research.