| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Reviews |
1 Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, United Kingdom and 2 Center for the Study of Reproductive Biology and Women's Health, Departments of Developmental and Molecular Biology and Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, New York
Requests for reprints: Claire E. Lewis, Academic Unit of Pathology, Division of Genomic Medicine, Floor E, The Henry Wellcome Laboratories for Medical Research, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, United Kingdom. Phone: 44-114-271-2903; Fax: 44-114-226-1464; E-mail: Claire.lewis{at}sheffield.ac.uk.
Macrophages are prominent in the stromal compartment of virtually all types of malignancy. These highly versatile cells respond to the presence of stimuli in different parts of tumors with the release of a distinct repertoire of growth factors, cytokines, chemokines, and enzymes that regulate tumor growth, angiogenesis, invasion, and/or metastasis. The distinct microenvironments where tumor-associated macrophages (TAM) act include areas of invasion where TAMs promote cancer cell motility, stromal and perivascular areas where TAMs promote metastasis, and avascular and perinecrotic areas where hypoxic TAMs stimulate angiogenesis. This review will discuss the evidence for differential regulation of TAMs in these microenvironments and provide an overview of current attempts to target or use TAMs for therapeutic purposes. (Cancer Res 2006; 66(2): 605-12)
This article has been cited by other articles:
![]() |
Y.-C. Chang, T.-C. Chen, C.-T. Lee, C.-Y. Yang, H.-W. Wang, C.-C. Wang, and S.-L. Hsieh Epigenetic control of MHC class II expression in tumor-associated macrophages by decoy receptor 3 Blood, May 15, 2008; 111(10): 5054 - 5063. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. A. Baltgalvis, F. G. Berger, M. M. O. Pena, J. M. Davis, and J. A. Carson Effect of exercise on biological pathways in ApcMin/+ mouse intestinal polyps J Appl Physiol, April 1, 2008; 104(4): 1137 - 1143. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Bierie, D. G. Stover, T. W. Abel, A. Chytil, A. E. Gorska, M. Aakre, E. Forrester, L. Yang, K.-U. Wagner, and H. L. Moses Transforming Growth Factor-{beta} Regulates Mammary Carcinoma Cell Survival and Interaction with the Adjacent Microenvironment Cancer Res., March 15, 2008; 68(6): 1809 - 1819. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. T. Stathopoulos, T. P. Sherrill, W. Han, R. T. Sadikot, F. E. Yull, T. S. Blackwell, and B. Fingleton Host Nuclear Factor-{kappa}B Activation Potentiates Lung Cancer Metastasis Mol. Cancer Res., March 1, 2008; 6(3): 364 - 371. [Abstract] [Full Text] [PDF] |
||||
![]() |
C.-H. Lee, I. Espinosa, S. Vrijaldenhoven, S. Subramanian, K. D. Montgomery, S. Zhu, R. J. Marinelli, J. L. Peterse, N. Poulin, T. O. Nielsen, et al. Prognostic Significance of Macrophage Infiltration in Leiomyosarcomas Clin. Cancer Res., March 1, 2008; 14(5): 1423 - 1430. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. K. Biswas, A. Sica, and C. E. Lewis Plasticity of Macrophage Function during Tumor Progression: Regulation by Distinct Molecular Mechanisms J. Immunol., February 15, 2008; 180(4): 2011 - 2017. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. S. Stearman, L. Dwyer-Nield, M. C. Grady, A. M. Malkinson, and M. W. Geraci A Macrophage Gene Expression Signature Defines a Field Effect in the Lung Tumor Microenvironment Cancer Res., January 1, 2008; 68(1): 34 - 43. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Braunstein, S. C. Formenti, and R. J. Schneider Acquisition of Stable Inducible Up-Regulation of Nuclear Factor-{kappa}B by Tumor Necrosis Factor Exposure Confers Increased Radiation Resistance without Increased Transformation in Breast Cancer Cells Mol. Cancer Res., January 1, 2008; 6(1): 78 - 88. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Duluc, Y. Delneste, F. Tan, M.-P. Moles, L. Grimaud, J. Lenoir, L. Preisser, I. Anegon, L. Catala, N. Ifrah, et al. Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells Blood, December 15, 2007; 110(13): 4319 - 4330. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Oflazoglu, I. J. Stone, K. A. Gordon, I. S. Grewal, N. van Rooijen, C.-L. Law, and H.-P. Gerber Macrophages contribute to the antitumor activity of the anti-CD30 antibody SGN-30 Blood, December 15, 2007; 110(13): 4370 - 4372. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Melani, S. Sangaletti, F. M. Barazzetta, Z. Werb, and M. P. Colombo Amino-Biphosphonate Mediated MMP-9 Inhibition Breaks the Tumor-Bone Marrow Axis Responsible for Myeloid-Derived Suppressor Cell Expansion and Macrophage Infiltration in Tumor Stroma Cancer Res., December 1, 2007; 67(23): 11438 - 11446. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. L. Gruen, M. Hao, D. W. Piston, and A. H. Hasty Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis Am J Physiol Cell Physiol, November 1, 2007; 293(5): C1481 - C1488. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. M. Montuenga and R. Pio Tumour-associated macrophages in nonsmall cell lung cancer: the role of interleukin-10 Eur. Respir. J., October 1, 2007; 30(4): 608 - 610. [Full Text] [PDF] |
||||
![]() |
A. Weigert, N. Tzieply, A. von Knethen, A. M. Johann, H. Schmidt, G. Geisslinger, and B. Brune Tumor Cell Apoptosis Polarizes Macrophages Role of Sphingosine-1-Phosphate Mol. Biol. Cell, October 1, 2007; 18(10): 3810 - 3819. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. E. Lewis, M. De Palma, and L. Naldini Tie2-Expressing Monocytes and Tumor Angiogenesis: Regulation by Hypoxia and Angiopoietin-2 Cancer Res., September 15, 2007; 67(18): 8429 - 8432. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Li, H. Du, Y. Qin, J. Roberts, O. W. Cummings, and C. Yan Activation of the Signal Transducers and Activators of the Transcription 3 Pathway in Alveolar Epithelial Cells Induces Inflammation and Adenocarcinomas in Mouse Lung Cancer Res., September 15, 2007; 67(18): 8494 - 8503. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Galarneau, J. Villeneuve, G. Gowing, J.-P. Julien, and L. Vallieres Increased Glioma Growth in Mice Depleted of Macrophages Cancer Res., September 15, 2007; 67(18): 8874 - 8881. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Wang, M. L. Madariaga, S. Wang, N. Van Rooijen, P.-A. Oldenborg, and Y.-G. Yang Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells PNAS, August 21, 2007; 104(34): 13744 - 13749. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Schade, S. H.L. Lam, D. Cernea, V. Sanguin-Gendreau, R. D. Cardiff, B. L. Jung, M. Hallett, and W. J. Muller Distinct ErbB-2 Coupled Signaling Pathways Promote Mammary Tumors with Unique Pathologic and Transcriptional Profiles Cancer Res., August 15, 2007; 67(16): 7579 - 7588. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Seike, N. Yanaihara, E. D. Bowman, K. A. Zanetti, A. Budhu, K. Kumamoto, L. E. Mechanic, S. Matsumoto, J. Yokota, T. Shibata, et al. Use of a Cytokine Gene Expression Signature in Lung Adenocarcinoma and the Surrounding Tissue as a Prognostic Classifier J Natl Cancer Inst, August 15, 2007; 99(16): 1257 - 1269. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Subramanian and C. Shaha Up-Regulation of Bcl-2 through ERK Phosphorylation Is Associated with Human Macrophage Survival in an Estrogen Microenvironment J. Immunol., August 15, 2007; 179(4): 2330 - 2338. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Sinha, V. K. Clements, S. K. Bunt, S. M. Albelda, and S. Ostrand-Rosenberg Cross-Talk between Myeloid-Derived Suppressor Cells and Macrophages Subverts Tumor Immunity toward a Type 2 Response J. Immunol., July 15, 2007; 179(2): 977 - 983. [Abstract] [Full Text] [PDF] |
||||
![]() |
D.-M. Kuang, Y. Wu, N. Chen, J. Cheng, S.-M. Zhuang, and L. Zheng Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes Blood, July 15, 2007; 110(2): 587 - 595. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. A. Venneri, M. D. Palma, M. Ponzoni, F. Pucci, C. Scielzo, E. Zonari, R. Mazzieri, C. Doglioni, and L. Naldini Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer Blood, June 15, 2007; 109(12): 5276 - 5285. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Y. Lin and J. W. Pollard Tumor-Associated Macrophages Press the Angiogenic Switch in Breast Cancer Cancer Res., June 1, 2007; 67(11): 5064 - 5066. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Cheng, D.-H. Huo, D.-M. Kuang, J. Yang, L. Zheng, and S.-M. Zhuang Human Macrophages Promote the Motility and Invasiveness of Osteopontin-Knockdown Tumor Cells Cancer Res., June 1, 2007; 67(11): 5141 - 5147. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Murdoch, S. Tazzyman, S. Webster, and C. E. Lewis Expression of Tie-2 by Human Monocytes and Their Responses to Angiopoietin-2 J. Immunol., June 1, 2007; 178(11): 7405 - 7411. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Schmidt, S. Suciu, C. J.A. Punt, M. Gore, W. Kruit, P. Patel, D. Lienard, H. von der Maase, A. M.M. Eggermont, and U. Keilholz Pretreatment Levels of Peripheral Neutrophils and Leukocytes As Independent Predictors of Overall Survival in Patients With American Joint Committee on Cancer Stage IV Melanoma: Results of the EORTC 18951 Biochemotherapy Trial J. Clin. Oncol., April 20, 2007; 25(12): 1562 - 1569. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. D.W. van der Bilt, M. E. Soeters, A. M.M.J. Duyverman, M. W. Nijkamp, P. O. Witteveen, P. J. van Diest, O. Kranenburg, and I. H.M. Borel Rinkes Perinecrotic Hypoxia Contributes to Ischemia/Reperfusion-Accelerated Outgrowth of Colorectal Micrometastases Am. J. Pathol., April 1, 2007; 170(4): 1379 - 1388. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Armani, E. Catalani, A. Balbarini, P. Bagnoli, and D. Cervia Expression, pharmacology, and functional role of somatostatin receptor subtypes 1 and 2 in human macrophages J. Leukoc. Biol., March 1, 2007; 81(3): 845 - 855. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. M. Park, Y. Kanaoka, N. Eguchi, K. Aritake, S. Grujic, A. M. Materi, V. S. Buslon, B. L. Tippin, A. M. Kwong, E. Salido, et al. Hematopoietic Prostaglandin D Synthase Suppresses Intestinal Adenomas in ApcMin/+ Mice Cancer Res., February 1, 2007; 67(3): 881 - 889. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Zins, D. Abraham, M. Sioud, and S. Aharinejad Colon Cancer Cell-Derived Tumor Necrosis Factor-{alpha} Mediates the Tumor Growth-Promoting Response in Macrophages by Up-regulating the Colony-Stimulating Factor-1 Pathway Cancer Res., February 1, 2007; 67(3): 1038 - 1045. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. F. Redente, D. J. Orlicky, R. J. Bouchard, and A. M. Malkinson Tumor Signaling to the Bone Marrow Changes the Phenotype of Monocytes and Pulmonary Macrophages during Urethane-Induced Primary Lung Tumorigenesis in A/J Mice Am. J. Pathol., February 1, 2007; 170(2): 693 - 708. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. W. Dewhirst, I. C. Navia, D. M. Brizel, C. Willett, and T. W. Secomb Multiple Etiologies of Tumor Hypoxia Require Multifaceted Solutions Clin. Cancer Res., January 15, 2007; 13(2): 375 - 377. [Full Text] [PDF] |
||||
![]() |
A. Budhu and X. W. Wang The role of cytokines in hepatocellular carcinoma J. Leukoc. Biol., December 1, 2006; 80(6): 1197 - 1213. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. L. Ramnaraine, W. E. Mathews, J. M. Donohue, C. M. Lynch, M. J. Goblirsch, and D. R. Clohisy Osteoclasts Direct Bystander Killing of Bone Cancer. Cancer Res., November 15, 2006; 66(22): 10929 - 10935. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. L HARKONEN and H. K. VAANANEN Monocyte-Macrophage System as a Target for Estrogen and Selective Estrogen Receptor Modulators Ann. N.Y. Acad. Sci., November 1, 2006; 1089(1): 218 - 227. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Lamagna, M. Aurrand-Lions, and B. A. Imhof Dual role of macrophages in tumor growth and angiogenesis J. Leukoc. Biol., October 1, 2006; 80(4): 705 - 713. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Wang, L. He, C. A. Combs, G. Roderiquez, and M. A. Norcross Dimerization of CXCR4 in living malignant cells: control of cell migration by a synthetic peptide that reduces homologous CXCR4 interactions. Mol. Cancer Ther., October 1, 2006; 5(10): 2474 - 2483. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Maruyama, M. Ono, A. Kawahara, T. Yokoyama, Y. Basaki, M. Kage, S. Aoyagi, H. Kinoshita, and M. Kuwano Tumor Growth Suppression in Pancreatic Cancer by a Putative Metastasis Suppressor Gene Cap43/NDRG1/Drg-1 through Modulation of Angiogenesis. Cancer Res., June 15, 2006; 66(12): 6233 - 6242. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. P. Nunez, W.-J. Oh, J. Rozenberg, C. Perella, M. Anver, J. C. Barrett, S. N. Perkins, D. Berrigan, J. Moitra, L. Varticovski, et al. Accelerated Tumor Formation in a Fatless Mouse with Type 2 Diabetes and Inflammation. Cancer Res., May 15, 2006; 66(10): 5469 - 5476. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Martin-Orozco and C. Dong New battlefields for costimulation J. Exp. Med., April 17, 2006; 203(4): 817 - 820. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Cell Growth & Differentiation |