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[Cancer Research 66, 812-819, January 15, 2006]
© 2006 American Association for Cancer Research

Cell, Tumor, and Stem Cell Biology

Overexpression of c-Maf Contributes to T-Cell Lymphoma in Both Mice and Human

Naoki Morito1, Keigyou Yoh2, Yuki Fujioka1, Takako Nakano1, Homare Shimohata1, Yuko Hashimoto1, Akiko Yamada1, Atsuko Maeda1, Fumihiko Matsuno5, Hiroyuki Hata5, Atsushi Suzuki6, Shigehiko Imagawa3, Hiroaki Mitsuya5, Hiroyasu Esumi6, Akio Koyama2, Masayuki Yamamoto4, Naoyoshi Mori7 and Satoru Takahashi1

1 Department of Anatomy and Embryology, Biomolecular and Integrated Medical Sciences, 2 Pathophysiology of Renal Diseases, Medical Sciences for Control of Pathological Processes, 3 Clinical and Experimental Hematology, Major of Advanced Biomedical Applications, 4 Graduate School of Comprehensive Human Sciences, Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Japan; 5 Department of Internal Medicine II, Kumamoto University School of Medicine, Kumamoto, Japan; 6 Cancer Physiology Project, National Cancer Center Research Institute East, Chiba, Japan; and 7 Department of Pathology of Biological Response, Nagoya University Graduate School of Medicine, Nagoya, Japan

Requests for reprints: Satoru Takahashi, Department of Anatomy and Embryology, Biomolecular and Integrated Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan. Phone: 81-298-53-7516; Fax: 81-298-53-6965; E-mail: satoruta{at}md.tsukuba.ac.jp.

c-Maf translocation or overexpression has been observed in human multiple myeloma. Although c-maf might function as an oncogene in multiple myeloma, a role for this gene in other cancers has not been shown. In this study, we have found that mice transgenic for c-Maf whose expression was direct to the T-cell compartment developed T-cell lymphoma. Moreover, we showed that cyclin D2, integrin ß7, and ARK5 were up-regulated in c-Maf transgenic lymphoma cells. Furthermore, 60% of human T-cell lymphomas (11 of 18 cases), classified as angioimmunoblastic T-cell lymphoma, were found to express c-Maf. These results suggest that c-Maf might cause a type of T-cell lymphoma in both mice and humans and that ARK5, in addition to cyclin D2 and integrin ß7, might be downstream target genes of c-Maf leading to malignant transformation. (Cancer Res 2006; 66(2): 812-9)




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2006 by the American Association for Cancer Research.