This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Erler, J. T. Articles by Giaccia, A. J. Search for Related Content PubMed PubMed Citation Articles by Erler, J. T. Articles by Giaccia, A. J. Related Collections Tumor Biology Tumor Biology: Invasion and Metastasis

Lysyl Oxidase Mediates Hypoxic Control of Metastasis

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California

Requests for reprints: Amato J. Giaccia, Department of Radiation Oncology, Stanford University School of Medicine, CCSR-S Room 1250, Stanford, CA 94305. Phone: 650-723-7439; Fax: 650-723-7382; E-mail: giaccia{at}stanford.edu.

Hypoxic cancer cells pose a great challenge to the oncologist because they are especially aggressive, metastatic, and resistant to therapy. Recently, we showed that elevation of the extracellular matrix protein lysyl oxidase (LOX) correlates with metastatic disease and is essential for hypoxia-induced metastasis. In an orthotopic rodent model of breast cancer, a small-molecule or antibody inhibitor of LOX abolished metastasis, offering preclinical validation of this enzyme as a therapeutic target. (Cancer Res 2006; 66(21): 10238-41)

This article has been cited by other articles:

				D. R. Cochrane, N. S. Spoelstra, E. N. Howe, S. K. Nordeen, and J. K. Richer MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents Mol. Cancer Ther., May 1, 2009; 8(5): 1055 - 1066. [Abstract] [Full Text] [PDF]

				M. B. Lowry, S. Lotinun, A. A. Leontovich, M. Zhang, A. Maran, K. L. Shogren, B. K. Palama, K. Marley, U. T. Iwaniec, and R. T. Turner Osteitis Fibrosa Is Mediated by Platelet-Derived Growth Factor-A Via a Phosphoinositide 3-Kinase-Dependent Signaling Pathway in a Rat Model for Chronic Hyperparathyroidism Endocrinology, November 1, 2008; 149(11): 5735 - 5746. [Abstract] [Full Text] [PDF]

				L. Zhang and R. P. Hill Hypoxia Enhances Metastatic Efficiency in HT1080 Fibrosarcoma Cells by Increasing Cell Survival in Lungs, Not Cell Adhesion and Invasion Cancer Res., August 15, 2007; 67(16): 7789 - 7797. [Abstract] [Full Text] [PDF]

				T.-M. Shieh, S.-C. Lin, C.-J. Liu, S.-S. Chang, T.-H. Ku, and K.-W. Chang Association of Expression Aberrances and Genetic Polymorphisms of Lysyl Oxidase with Areca-Associated Oral Tumorigenesis Clin. Cancer Res., August 1, 2007; 13(15): 4378 - 4385. [Abstract] [Full Text] [PDF]