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Quantitating Therapeutic Disruption of Tumor Blood Flow with Intravital Video Microscopy

¹ GI & Hepatobiliary Research Unit, Academic Division of Surgical and Interventional Sciences, University College London and ² Department of Surgery, Royal Free Hampstead NHS Trust Hospital, London, United Kingdom

Requests for reprints: Alexander M. Seifalian, Academic Division of Surgical and Interventional Sciences, University College London, Rowland Hill Street, London NW3 2PF, United Kingdom. Phone: 44-20-7830-2901; Fax: 44-20-7472-6444; E-mail: a.seifalian{at}medsch.ucl.ac.uk.

Vascular-disrupting agents (VDA) kill tumor cells by selectively disrupting blood circulation in tumors. In vivo analysis of this intensely studied class of anticancer agents is invaluable for preclinical assessment of pharmacodynamic end points and effective therapeutic windows. In this review, we consider the role of intravital video microscopy in measuring tumor vascular response to VDAs, the potential of which lies in the opportunity to quantitate specific variables and to obtain real-time information on how VDAs affect tumor microcirculation. (Cancer Res 2006; 66(24): 11517-9)