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Eighteenth Annual Pezcoller Symposium: Tumor Microenvironment and Heterotypic Interactions

¹ Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts and ² Pharmacology and Therapeutics Department, Roswell Park Cancer Institute, Buffalo, New York

Requests for reprints: Enrico Mihich, Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263. Phone: 716-845-3314; Fax: 716-845-3351; E-mail: enrico.mihich{at}roswellpark.org.

This symposium was held in Trento, Italy, from June 27 to 29, 2006, and was co-chaired by Robert Weinberg and Enrico Mihich. The interactions between tumor cells and their microenvironment were discussed with particular emphasis on their molecular mechanisms. The roles of transforming growth factor ß signaling, urokinase, and matrix metalloproteinases in matrix remodeling; the effects of matrix-tumor interactions on cell proliferation and migration; the tumor-promoting effects of inflammation and of related host cell and cytokine functions; the signaling mechanisms affecting the biology of the stroma; and the mechanisms governing angiogenesis were discussed. (Cancer Res 2006; 66(24): 11550-3)

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