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[Cancer Research 66, 1265-1269, February 1, 2006]
© 2006 American Association for Cancer Research

Priority Reports

Bone Marrow–Derived Stromal Cells Express Lineage-Related Messenger RNA Species

Natalie C. Direkze1,3, Rosemary Jeffery1, Kairbaan Hodivala-Dilke1,2, Toby Hunt1, Raymond J. Playford3, George Elia1, Richard Poulsom1, Nicholas A. Wright1,2 and Malcolm R. Alison1,2

1 Cancer Research UK; 2 Barts and the London; and 3 Imperial College London, London, United Kingdom

Requests for reprints: Natalie C. Direkze, Histopathology Unit, Cancer Research UK, 44 Lincolns Inn Fields, London WC2A 3PX, United Kingdom. Phone: 44-207-269-3434; Fax: 11-44-207-269-3491; E-mail: Natalie.direkze{at}cancer.org.uk.

Evidence has emerged that bone marrow cells have a greater degree of plasticity than previously thought. However, there has been a call to establish proof that these bone marrow–derived cells function appropriately in their new environment. We have already shown that the bone marrow contributes to myofibroblasts in multiple organs and that this is exacerbated by injury and occurs in a mouse tumor model. Here, we provide evidence that these cells are functioning appropriately by showing that bone marrow–derived myofibroblasts are expressing mRNA for the {alpha}1 chain of type I (pro)collagen using a new customized technique. This provides evidence that the bone marrow-tumor stroma axis is functionally relevant and may therefore subsequently be exploited to develop new strategies for anticancer therapy. (Cancer Res 2006; 66(3): 1265-9)




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Copyright © 2006 by the American Association for Cancer Research.