Cancer Research Targets Advances in Breast Cancer Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Konecny, G. E.
Right arrow Articles by Slamon, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Konecny, G. E.
Right arrow Articles by Slamon, D. J.
[Cancer Research 66, 1630-1639, February 1, 2006]
© 2006 American Association for Cancer Research

Experimental Therapeutics, Molecular Targets, and Chemical Biology

Activity of the Dual Kinase Inhibitor Lapatinib (GW572016) against HER-2-Overexpressing and Trastuzumab-Treated Breast Cancer Cells

Gottfried E. Konecny1,2, Mark D. Pegram1, Natarajan Venkatesan1, Richard Finn1, Guorong Yang1, Martina Rahmeh3, Michael Untch3, David W. Rusnak4, Glenn Spehar4, Robert J. Mullin5, Barry R. Keith4, Tona M. Gilmer4, Mark Berger6, Karl C. Podratz2 and Dennis J. Slamon1

1 Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles and Jonsson Comprehensive Cancer Center, Los Angeles, California; 2 Department of Gynecologic Surgery, Mayo Clinic, Rochester, Minnesota; 3 Department of Obstetrics and Gynecology, Klinikum Grosshadern, Ludwig Maximilians Universität München, Munich, Germany; 4 GlaxoSmithKline, Research Triangle Park, North Carolina; 5 Piedmont Research Center, Morrisville, North Carolina; and 6 GlaxoSmithKline, Collegeville, Pennsylvania

Requests for reprints: Gottfried E. Konecny, Division of Hematology-Oncology, University of California at Los Angeles, 12-145 Factor Building, 10945 Le Conte Avenue, Los Angeles, CA 90095-1678. E-mail: gkonecny{at}ucla.edu.

Lapatinib (GW572016) is a selective inhibitor of both epidermal growth factor receptor (EGFR) and HER-2 tyrosine kinases. Here, we explore the therapeutic potential of lapatinib by testing its effect on tumor cell growth in a panel of 31 characterized human breast cancer cell lines, including trastuzumab-conditioned HER-2-positive cell lines. We further characterize its activity in combination with trastuzumab and analyze whether EGFR and HER-2 expression or changes induced in the activation of EGFR, HER-2, Raf, AKT, or extracellular signal-regulated kinase (ERK) are markers of drug activity. We report that concentration-dependent antiproliferative effects of lapatinib were seen in all breast cancer cell lines tested but varied significantly between individual cell lines with up to 1,000-fold difference in the IC50s (range, 0.010-18.6 µmol/L). Response to lapatinib was significantly correlated with HER-2 expression and its ability to inhibit HER-2, Raf, AKT, and ERK phosphorylation. Long-term in vivo lapatinib studies were conducted with human breast cancer xenografts in athymic mice. Treatment over 77 days resulted in a sustained and significant reduction in xenograft volume compared with untreated controls. For the combination of lapatinib plus trastuzumab, synergistic drug interactions were observed in four different HER-2-overexpressing cell lines. Moreover, lapatinib retained significant in vitro activity against cell lines selected for long-term outgrowth (>9 months) in trastuzumab-containing (100 µg/mL) culture medium. These observations provide a clear biological rationale to test lapatinib as a single agent or in combination with trastuzumab in HER-2-overexpressing breast cancer and in patients with clinical resistance to trastuzumab. (Cancer Res 2006; 66(3): 1630-9)




This article has been cited by other articles:


Home page
 Ann OncolHome page
K. L. Blackwell, M. D. Pegram, E. Tan-Chiu, L. S. Schwartzberg, M. C. Arbushites, J. D. Maltzman, J. K. Forster, S. D. Rubin, S. H. Stein, and H. J. Burstein
Single-agent lapatinib for HER2-overexpressing advanced or metastatic breast cancer that progressed on first- or second-line trastuzumab-containing regimens
Ann. Onc., June 1, 2009; 20(6): 1026 - 1031.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
M. Dokmanovic, D. S. Hirsch, Y. Shen, and W. J. Wu
Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer
Mol. Cancer Ther., June 1, 2009; 8(6): 1557 - 1569.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Brognard, M. Niederst, G. Reyes, N. Warfel, and A. C. Newton
Common Polymorphism in the Phosphatase PHLPP2 Results in Reduced Regulation of Akt and Protein Kinase C
J. Biol. Chem., May 29, 2009; 284(22): 15215 - 15223.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
T. E. Strecker, Q. Shen, Y. Zhang, J. L. Hill, Y. Li, C. Wang, H.-T. Kim, T. M. Gilmer, K. R. Sexton, S. G. Hilsenbeck, et al.
Effect of Lapatinib on the Development of Estrogen Receptor-Negative Mammary Tumors in Mice
J Natl Cancer Inst, January 21, 2009; 101(2): 107 - 113.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. R. Molina, S. H. Kaufmann, J. M. Reid, S. D. Rubin, M. Galvez-Peralta, R. Friedman, K. S. Flatten, K. M. Koch, T. M. Gilmer, R. J. Mullin, et al.
Evaluation of Lapatinib and Topotecan Combination Therapy: Tissue Culture, Murine Xenograft, and Phase I Clinical Trial Data
Clin. Cancer Res., December 1, 2008; 14(23): 7900 - 7908.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. J.A. Eichhorn, M. Gili, M. Scaltriti, V. Serra, M. Guzman, W. Nijkamp, R. L. Beijersbergen, V. Valero, J. Seoane, R. Bernards, et al.
Phosphatidylinositol 3-Kinase Hyperactivation Results in Lapatinib Resistance that Is Reversed by the mTOR/Phosphatidylinositol 3-Kinase Inhibitor NVP-BEZ235
Cancer Res., November 15, 2008; 68(22): 9221 - 9230.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
F. L. Chen, W. Xia, and N. L. Spector
Acquired Resistance to Small Molecule ErbB2 Tyrosine Kinase Inhibitors
Clin. Cancer Res., November 1, 2008; 14(21): 6730 - 6734.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. J. Duffy and J. Crown
A Personalized Approach to Cancer Treatment: How Biomarkers Can Help
Clin. Chem., November 1, 2008; 54(11): 1770 - 1779.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
Q. Ryan, A. Ibrahim, M. H. Cohen, J. Johnson, C.-w. Ko, R. Sridhara, R. Justice, and R. Pazdur
FDA Drug Approval Summary: Lapatinib in Combination with Capecitabine for Previously Treated Metastatic Breast Cancer That Overexpresses HER-2
Oncologist, October 1, 2008; 13(10): 1114 - 1119.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
A. P. Martin, A. Miller, L. Emad, M. Rahmani, T. Walker, C. Mitchell, M. P. Hagan, M. A. Park, A. Yacoub, P. B. Fisher, et al.
Lapatinib Resistance in HCT116 Cells Is Mediated by Elevated MCL-1 Expression and Decreased BAK Activation and Not by ERBB Receptor Kinase Mutation
Mol. Pharmacol., September 1, 2008; 74(3): 807 - 822.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
B. Gril, D. Palmieri, J. L. Bronder, J. M. Herring, E. Vega-Valle, L. Feigenbaum, D. J. Liewehr, S. M. Steinberg, M. J. Merino, S. D. Rubin, et al.
Effect of Lapatinib on the Outgrowth of Metastatic Breast Cancer Cells to the Brain
J Natl Cancer Inst, August 6, 2008; 100(15): 1092 - 1103.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. T. Lee-Hoeflich, L. Crocker, E. Yao, T. Pham, X. Munroe, K. P. Hoeflich, M. X. Sliwkowski, and H. M. Stern
A Central Role for HER3 in HER2-Amplified Breast Cancer: Implications for Targeted Therapy
Cancer Res., July 15, 2008; 68(14): 5878 - 5887.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. M. Storniolo, M. D. Pegram, B. Overmoyer, P. Silverman, N. W. Peacock, S. F. Jones, J. Loftiss, N. Arya, K. M. Koch, E. Paul, et al.
Phase I Dose Escalation and Pharmacokinetic Study of Lapatinib in Combination With Trastuzumab in Patients With Advanced ErbB2-Positive Breast Cancer
J. Clin. Oncol., July 10, 2008; 26(20): 3317 - 3323.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
H. W. Hirte and S. J. Hotte
Dual-Agent Molecular Targeting of the ErbB2 Receptor: Killing One Bird With Two Stones
J. Clin. Oncol., July 10, 2008; 26(20): 3301 - 3302.
[Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
D. Zhang, A. Pal, W. G. Bornmann, F. Yamasaki, F. J. Esteva, G. N. Hortobagyi, C. Bartholomeusz, and N. T. Ueno
Activity of lapatinib is independent of EGFR expression level in HER2-overexpressing breast cancer cells
Mol. Cancer Ther., July 1, 2008; 7(7): 1846 - 1850.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
H.-J. Stemmler and V. Heinemann
Central Nervous System Metastases in HER-2-Overexpressing Metastatic Breast Cancer: A Treatment Challenge
Oncologist, July 1, 2008; 13(7): 739 - 750.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
H. L. Gomez, D. C. Doval, M. A. Chavez, P. C.-S. Ang, Z. Aziz, S. Nag, C. Ng, S. X. Franco, L. W.C. Chow, M. C. Arbushites, et al.
Efficacy and Safety of Lapatinib As First-Line Therapy for ErbB2-Amplified Locally Advanced or Metastatic Breast Cancer
J. Clin. Oncol., June 20, 2008; 26(18): 2999 - 3005.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. B. Lee, M. Hassan, R. Fisher, O. Chertov, V. Chernomordik, G. Kramer-Marek, A. Gandjbakhche, and J. Capala
Affibody Molecules for In vivo Characterization of HER2-Positive Tumors by Near-Infrared Imaging
Clin. Cancer Res., June 15, 2008; 14(12): 3840 - 3849.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
A. Vazquez-Martin, C. Oliveras-Ferraros, R. Colomer, J. Brunet, and J. A. Menendez
Low-scale phosphoproteome analyses identify the mTOR effector p70 S6 kinase 1 as a specific biomarker of the dual-HER1/HER2 tyrosine kinase inhibitor lapatinib (Tykerb(R)) in human breast carcinoma cells
Ann. Onc., June 1, 2008; 19(6): 1097 - 1109.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
H. J. Burstein, A. M. Storniolo, S. Franco, J. Forster, S. Stein, S. Rubin, V. M. Salazar, and K. L. Blackwell
A phase II study of lapatinib monotherapy in chemotherapy-refractory HER2-positive and HER2-negative advanced or metastatic breast cancer
Ann. Onc., June 1, 2008; 19(6): 1068 - 1074.
[Abstract] [Full Text] [PDF]

Home page
 aacredbookHome page
N. E Hynes
ErbB Receptors in Cancer: HER2/ErbB2 as a Therapeutic Target
Am. Assoc. Cancer Res. Educ. Book, April 12, 2008; 2008(1): 123 - 130.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. Kumar, E. T. Petri, B. Halmos, and T. J. Boggon
Structure and Clinical Relevance of the Epidermal Growth Factor Receptor in Human Cancer
J. Clin. Oncol., April 1, 2008; 26(10): 1742 - 1751.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
J. Greshock, J. Cheng, D. Rusnak, A. M. Martin, R. Wooster, T. Gilmer, K. Lee, B. L. Weber, and T. Zaks
Genome-wide DNA copy number predictors of lapatinib sensitivity in tumor-derived cell lines
Mol. Cancer Ther., April 1, 2008; 7(4): 935 - 943.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. Johnston, M. Trudeau, B. Kaufman, H. Boussen, K. Blackwell, P. LoRusso, D. P. Lombardi, S. Ben Ahmed, D. L. Citrin, M. L. DeSilvio, et al.
Phase II Study of Predictive Biomarker Profiles for Response Targeting Human Epidermal Growth Factor Receptor 2 (HER-2) in Advanced Inflammatory Breast Cancer With Lapatinib Monotherapy
J. Clin. Oncol., March 1, 2008; 26(7): 1066 - 1072.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
H.-P. Kim, S.-W. Han, S.-H. Kim, S.-A. Im, D.-Y. Oh, Y.-J. Bang, and T.-Y. Kim
Combined lapatinib and cetuximab enhance cytotoxicity against gefitinib-resistant lung cancer cells
Mol. Cancer Ther., March 1, 2008; 7(3): 607 - 615.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
K. M. Aird, X. Ding, A. Baras, J. Wei, M. A. Morse, T. Clay, H. K. Lyerly, and G. R. Devi
Trastuzumab signaling in ErbB2-overexpressing inflammatory breast cancer correlates with X-linked inhibitor of apoptosis protein expression
Mol. Cancer Ther., January 1, 2008; 7(1): 38 - 47.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
O. Rixe and T. Fojo
Is Cell Death a Critical End Point for Anticancer Therapies or Is Cytostasis Sufficient?
Clin. Cancer Res., December 15, 2007; 13(24): 7280 - 7287.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
J. Krol, R. E. Francis, A. Albergaria, A. Sunters, A. Polychronis, R. C. Coombes, and E. W.-F. Lam
The transcription factor FOXO3a is a crucial cellular target of gefitinib (Iressa) in breast cancer cells
Mol. Cancer Ther., December 1, 2007; 6(12): 3169 - 3179.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Barrett, Y. Koyama, Y. Hama, G. Ravizzini, I. S. Shin, B.-S. Jang, C. H. Paik, Y. Urano, P. L. Choyke, and H. Kobayashi
In vivo Diagnosis of Epidermal Growth Factor Receptor Expression using Molecular Imaging with a Cocktail of Optically Labeled Monoclonal Antibodies
Clin. Cancer Res., November 15, 2007; 13(22): 6639 - 6648.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. P. Jani, R. S. Finn, M. Campbell, K. G. Coleman, R. D. Connell, N. Currier, E. O. Emerson, E. Floyd, S. Harriman, J. C. Kath, et al.
Discovery and Pharmacologic Characterization of CP-724,714, a Selective ErbB2 Tyrosine Kinase Inhibitor
Cancer Res., October 15, 2007; 67(20): 9887 - 9893.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. A. Ritter, M. Perez-Torres, C. Rinehart, M. Guix, T. Dugger, J. A. Engelman, and C. L. Arteaga
Human Breast Cancer Cells Selected for Resistance to Trastuzumab In vivo Overexpress Epidermal Growth Factor Receptor and ErbB Ligands and Remain Dependent on the ErbB Receptor Network
Clin. Cancer Res., August 15, 2007; 13(16): 4909 - 4919.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. L. Spector, Y. Yarden, B. Smith, L. Lyass, P. Trusk, K. Pry, J. E. Hill, W. Xia, R. Seger, and S. S. Bacus
Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells
PNAS, June 19, 2007; 104(25): 10607 - 10612.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Magnifico, L. Albano, S. Campaner, M. Campiglio, S. Pilotti, S. Menard, and E. Tagliabue
Protein Kinase C{alpha} Determines HER2 Fate in Breast Carcinoma Cells with HER2 Protein Overexpression without Gene Amplification
Cancer Res., June 1, 2007; 67(11): 5308 - 5317.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. Larbouret, B. Robert, I. Navarro-Teulon, S. Thezenas, M.-Z. Ladjemi, S. Morisseau, E. Campigna, F. Bibeau, J.-P. Mach, A. Pelegrin, et al.
In vivo Therapeutic Synergism of Anti-Epidermal Growth Factor Receptor and Anti-HER2 Monoclonal Antibodies against Pancreatic Carcinomas
Clin. Cancer Res., June 1, 2007; 13(11): 3356 - 3362.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. S. Ross, W. F. Symmans, L. Pusztai, and G. N. Hortobagyi
Standardizing Slide-Based Assays in Breast Cancer: Hormone Receptors, HER2, and Sentinel Lymph Nodes
Clin. Cancer Res., May 15, 2007; 13(10): 2831 - 2835.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Palmieri, J. L. Bronder, J. M. Herring, T. Yoneda, R. J. Weil, A. M. Stark, R. Kurek, E. Vega-Valle, L. Feigenbaum, D. Halverson, et al.
Her-2 Overexpression Increases the Metastatic Outgrowth of Breast Cancer Cells in the Brain
Cancer Res., May 1, 2007; 67(9): 4190 - 4198.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
D. Tripathy
Capecitabine in Combination with Novel Targeted Agents in the Management of Metastatic Breast Cancer: Underlying Rationale and Results of Clinical Trials
Oncologist, April 1, 2007; 12(4): 375 - 389.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
J. T. Jorgensen, K. V. Nielsen, and B. Ejlertsen
Pharmacodiagnostics and Targeted Therapies--A Rational Approach for Individualizing Medical Anticancer Therapy in Breast Cancer
Oncologist, April 1, 2007; 12(4): 397 - 405.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
V. Tolmachev, A. Orlova, R. Pehrson, J. Galli, B. Baastrup, K. Andersson, M. Sandstrom, D. Rosik, J. Carlsson, H. Lundqvist, et al.
Radionuclide Therapy of HER2-Positive Microxenografts Using a 177Lu-Labeled HER2-Specific Affibody Molecule
Cancer Res., March 15, 2007; 67(6): 2773 - 2782.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. S. Fridman, E. Caulder, M. Hansbury, X. Liu, G. Yang, Q. Wang, Y. Lo, B.-B. Zhou, M. Pan, S. M. Thomas, et al.
Selective Inhibition of ADAM Metalloproteases as a Novel Approach for Modulating ErbB Pathways in Cancer
Clin. Cancer Res., March 15, 2007; 13(6): 1892 - 1902.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. Lutterbach, Q. Zeng, L. J. Davis, H. Hatch, G. Hang, N. E. Kohl, J. B. Gibbs, and B.-S. Pan
Lung Cancer Cell Lines Harboring MET Gene Amplification Are Dependent on Met for Growth and Survival
Cancer Res., March 1, 2007; 67(5): 2081 - 2088.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
W. Xia, I. Husain, L. Liu, S. Bacus, S. Saini, J. Spohn, K. Pry, R. Westlund, S. H. Stein, and N. L. Spector
Lapatinib Antitumor Activity Is Not Dependent upon Phosphatase and Tensin Homologue Deleted on Chromosome 10 in ErbB2-Overexpressing Breast Cancers
Cancer Res., February 1, 2007; 67(3): 1170 - 1175.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
R. Nahta, L. X.H. Yuan, Y. Du, and F. J. Esteva
Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: effects on insulin-like growth factor I signaling
Mol. Cancer Ther., February 1, 2007; 6(2): 667 - 674.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. G. Dolloff, M. R. Russell, N. Loizos, and A. Fatatis
Human Bone Marrow Activates the Akt Pathway in Metastatic Prostate Cells through Transactivation of the {alpha}-Platelet-Derived Growth Factor Receptor
Cancer Res., January 15, 2007; 67(2): 555 - 562.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
C. E. Geyer, J. Forster, D. Lindquist, S. Chan, C. G. Romieu, T. Pienkowski, A. Jagiello-Gruszfeld, J. Crown, A. Chan, B. Kaufman, et al.
Lapatinib plus Capecitabine for HER2-Positive Advanced Breast Cancer
N. Engl. J. Med., December 28, 2006; 355(26): 2733 - 2743.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
F. Meric-Bernstam and M.-C. Hung
Advances in targeting human epidermal growth factor receptor-2 signaling for cancer therapy.
Clin. Cancer Res., November 1, 2006; 12(21): 6326 - 6330.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
B. Moy and P. E. Goss
Lapatinib: Current Status and Future Directions in Breast Cancer
Oncologist, November 1, 2006; 11(10): 1047 - 1057.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W. Xia, S. Bacus, P. Hegde, I. Husain, J. Strum, L. Liu, G. Paulazzo, L. Lyass, P. Trusk, J. Hill, et al.
A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer
PNAS, May 16, 2006; 103(20): 7795 - 7800.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2006 by the American Association for Cancer Research.