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Cancer Risk Assessment at the Atomic Level

¹ Risk Assessment, Detection, and Intervention Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida and ² Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota

Requests for reprints: Alvaro N.A. Monteiro, Risk Assessment, Detection, and Intervention Program, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612. Phone: 813-745-6321; Fax: 813-745-1720; E-mail: monteian{at}moffitt.usf.edu.

Abstract

A flurry of articles on the structure of different domains of BRCA1 and BRCA2 have not only shed light on the biology of these proteins but have also raised hopes that these data could eventually be used to infer cancer association for a large number of inherited missense mutations whose effect on protein function is unclear. (Cancer Res 2006; 66(4): 1897-9)

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