| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Epidemiology and Prevention |
1 Department of Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, Georgia; 2 Department of Epidemiology and 3 Program in Molecular and Genetic Epidemiology, Harvard School of Public Health; 4 Division of Preventive Medicine and 5 Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; 6 Foundation Jean Dausset, CEPH, Paris, France; 7 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland; 8 Hormones and Cancer Group and 9 Unit of Nutrition and Cancer, IARC, Lyon, France; 10 Keck School of Medicine and 11 Division of Biostatistics and Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 12 Broad Institute at Harvard and Massachusetts Institute of Technology; 13 Whitehead Institute for Biomedical Research, Cambridge, Massachusetts; 14 Department of Medicine, Lund University, Malmö, Sweden; 15 Epidemiology Unit, National Cancer Institute, Milan, Italy; 16 Medical Research Council Dunn Nutrition Unit, Cambridge, United Kingdom; 17 Core Genotyping Facility, National Cancer Institute, Gaithersburg, Maryland; 18 Institut National de la Sante et de la Recherche Medicale, Institut Gustave Roussy, Villejuif, France; 19 Cancer Research Center, University of Hawaii, Honolulu, Hawaii; 20 Division of Clinical Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany; 21 Epidemiology Department, Murcia Health Council, Murcia, Spain; 22 Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; 23 Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark; and 24 Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
Requests for reprints: Heather Spencer Feigelson, Department of Epidemiology and Surveillance Research, American Cancer Society, 1599 Clifton Road Northeast, Atlanta, GA 30329. Phone: 404-929-6815; Fax: 404-327-6450; E-mail: heather.feigelson{at}cancer.org.
The 17ß-hydroxysteroid dehydrogenase 1 gene (HSD17B1) encodes 17HSD1, which catalyzes the final step of estradiol biosynthesis. Despite the important role of HSD17B1 in hormone metabolism, few epidemiologic studies of HSD17B1 and breast cancer have been conducted. This study includes 5,370 breast cancer cases and 7,480 matched controls from five large cohorts in the Breast and Prostate Cancer Cohort Consortium. We characterized variation in HSD17B1 by resequencing and dense genotyping a multiethnic sample and identified haplotype-tagging single nucleotide polymorphisms (htSNP) that capture common variation within a 33.3-kb region around HSD17B1. Four htSNPs, including the previously studied SNP rs605059 (S312G), were genotyped to tag five common haplotypes in all cases and controls. Conditional logistic regression was used to estimate odds ratios (OR) for disease. We found no evidence of association between common HSD17B1 haplotypes or htSNPs and overall risk of breast cancer. The OR for each haplotype relative to the most common haplotype ranged from 0.98 to 1.07 (omnibus test for association: X2 = 3.77, P = 0.58, 5 degrees of freedom). When cases were subdivided by estrogen receptor (ER) status, two common haplotypes were associated with ER-negative tumors (test for trend, Ps = 0.0009 and 0.0076; n = 353 cases). HSD17B1 variants that are common in Caucasians are not associated with overall risk of breast cancer; however, there was an association among the subset of ER-negative tumors. Although the probability that these ER-negative findings are false-positive results is high, these findings were consistent across each cohort examined and warrant further study. (Cancer Res 2006; 66(4): 2468-75)
This article has been cited by other articles:
|
|
 |
|
  J. D. McKay, M. L. McCullough, R. G. Ziegler, P. Kraft, B. S. Saltzman, E. Riboli, A. Barricarte, C. D. Berg, G. Bergland, S. Bingham, et al. Vitamin D Receptor Polymorphisms and Breast Cancer Risk: Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium Cancer Epidemiol. Biomarkers Prev., January 1, 2009; 18(1): 297 - 305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. D. Freedman, J. Ahn, L. Hou, J. Lissowska, W. Zatonski, M. Yeager, S. J. Chanock, W. H. Chow, and C. C. Abnet Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer Carcinogenesis, January 1, 2009; 30(1): 71 - 77. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wacholder, N. Chatterjee, and N. Caporaso Intermediacy and Gene-Environment Interaction: The Example of CHRNA5-A3 Region, Smoking, Nicotine Dependence, and Lung Cancer J Natl Cancer Inst, November 5, 2008; 100(21): 1488 - 1491. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hamaguchi, M. Nishio, T. Toyama, H. Sugiura, N. Kondo, Y. Fujii, and H. Yamashita Possible Difference in Frequencies of Genetic Polymorphisms of Estrogen Receptor {alpha}, Estrogen Metabolism and P53 Genes Between Estrogen Receptor-positive and -negative Breast Cancers Jpn. J. Clin. Oncol., November 1, 2008; 38(11): 734 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Gaudet, S. Chanock, A. Dunning, K. Driver, L. A. Brinton, J. Lissowska, B. Peplonska, P. Pharoah, and M. Garcia-Closas HSD17B1 Genetic Variants and Hormone Receptor-Defined Breast Cancer Cancer Epidemiol. Biomarkers Prev., October 1, 2008; 17(10): 2766 - 2772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. I. Phipps, K. E. Malone, P. L. Porter, J. R. Daling, and C. I. Li Body Size and Risk of Luminal, HER2-Overexpressing, and Triple-Negative Breast Cancer in Postmenopausal Women Cancer Epidemiol. Biomarkers Prev., August 1, 2008; 17(8): 2078 - 2086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhao, L.-E Wang, D. Li, R. M. Chamberlain, E. M. Sturgis, and Q. Wei Genotypes and haplotypes of ERCC1 and ERCC2/XPD genes predict levels of benzo[a]pyrene diol epoxide-induced DNA adducts in cultured primary lymphocytes from healthy individuals: a genotype-phenotype correlation analysis Carcinogenesis, August 1, 2008; 29(8): 1560 - 1566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Sakoda, C. Blackston, J. A. Doherty, R. M. Ray, M. G. Lin, H. Stalsberg, D. L. Gao, Z. Feng, D. B. Thomas, and C. Chen Polymorphisms in Steroid Hormone Biosynthesis Genes and Risk of Breast Cancer and Fibrocystic Breast Conditions in Chinese Women Cancer Epidemiol. Biomarkers Prev., May 1, 2008; 17(5): 1066 - 1073. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Editor's Note Cancer Res., May 1, 2008; 68(9): 3550 - 3550. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Plourde, C. Manhes, G. Leblanc, F. Durocher, M. Dumont, O. Sinilnikova, I. BRCAs, and J. Simard Mutation analysis and characterization of HSD17B2 sequence variants in breast cancer cases from French Canadian families with high risk of breast and ovarian cancer J. Mol. Endocrinol., April 1, 2008; 40(4): 161 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. W. Setiawan, F. R. Schumacher, C. A. Haiman, D. O. Stram, D. Albanes, D. Altshuler, G. Berglund, J. Buring, E. E. Calle, F. Clavel-Chapelon, et al. CYP17 Genetic Variation and Risk of Breast and Prostate Cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3) Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2237 - 2246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Dallal, J. Sullivan-Halley, R. K. Ross, Y. Wang, D. Deapen, P. L. Horn-Ross, P. Reynolds, D. O. Stram, C. A. Clarke, H. Anton-Culver, et al. Long-term Recreational Physical Activity and Risk of Invasive and In Situ Breast Cancer: The California Teachers Study Arch Intern Med, February 26, 2007; 167(4): 408 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. A. Ioannidis Common genetic variants for breast cancer: 32 largely refuted candidates and larger prospects. J Natl Cancer Inst, October 4, 2006; 98(19): 1350 - 1353. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
