Cancer Research Prevention Award Frontiers in Basic Cancer Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Krishnamachary, B.
Right arrow Articles by Semenza, G. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Krishnamachary, B.
Right arrow Articles by Semenza, G. L.
[Cancer Research 66, 2725-2731, March 1, 2006]
© 2006 American Association for Cancer Research

Cell, Tumor, and Stem Cell Biology

Hypoxia-Inducible Factor-1-Dependent Repression of E-cadherin in von Hippel-Lindau Tumor Suppressor–Null Renal Cell Carcinoma Mediated by TCF3, ZFHX1A, and ZFHX1B

Balaji Krishnamachary1, David Zagzag2, Hideko Nagasawa1, Karin Rainey1, Hiroaki Okuyama1, Jin H. Baek1 and Gregg L. Semenza1

1 Vascular Biology Program, Institute for Cell Engineering; Departments of Pediatrics, Medicine, Oncology, and Radiation Oncology; and McKusick-Nathans Institute for Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland; and 2 Microvascular and Molecular Neuro-Oncology Laboratory, Departments of Pathology and Neurosurgery, New York University Cancer Institute of New York University School of Medicine, New York, New York

Requests for reprints: Gregg L. Semenza, Johns Hopkins University School of Medicine, Broadway Research Building, 733 North Broadway, Suite 671, Baltimore, MD 21205. Fax: 443-287-5618; E-mail: gsemenza{at}jhmi.edu.

A critical event in the pathogenesis of invasive and metastatic cancer is E-cadherin loss of function. Renal clear cell carcinoma (RCC) is characterized by loss of function of the von Hippel-Lindau tumor suppressor (VHL), which negatively regulates hypoxia-inducible factor-1 (HIF-1). Loss of E-cadherin expression and decreased cell-cell adhesion in VHL-null RCC4 cells were corrected by enforced expression of VHL, a dominant-negative HIF-1{alpha} mutant, or a short hairpin RNA directed against HIF-1{alpha}. In human RCC biopsies, expression of E-cadherin and HIF-1{alpha} was mutually exclusive. The expression of mRNAs encoding TCF3, ZFHX1A, and ZFHX1B, which repress E-cadherin gene transcription, was increased in VHL-null RCC4 cells in a HIF-1–dependent manner. Thus, HIF-1 contributes to the epithelial-mesenchymal transition in VHL-null RCC by indirect repression of E-cadherin. (Cancer Res 2006; 66(5): 2725-31)




This article has been cited by other articles:


Home page
 Molecular Cancer TherapeuticsHome page
T. Liu, C. P. Masamha, S. Chengedza, K. D. Berlin, S. Lightfoot, F. He, and D. M. Benbrook
Development of flexible-heteroarotinoids for kidney cancer
Mol. Cancer Ther., May 1, 2009; 8(5): 1227 - 1238.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
I. Wacker, M. Sachs, K. Knaup, M. Wiesener, J. Weiske, O. Huber, Z. Akcetin, and J. Behrens
Key Role for Activin B in Cellular Transformation after Loss of the von Hippel-Lindau Tumor Suppressor
Mol. Cell. Biol., April 1, 2009; 29(7): 1707 - 1718.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Scortegagna, R. J. Martin, R. D. Kladney, R. G. Neumann, and J. M. Arbeit
Hypoxia-Inducible Factor-1{alpha} Suppresses Squamous Carcinogenic Progression and Epithelial-Mesenchymal Transition
Cancer Res., March 15, 2009; 69(6): 2638 - 2646.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
S. K. Harten, D. Shukla, R. Barod, A. Hergovich, M. S. Balda, K. Matter, M. A. Esteban, and P. H. Maxwell
Regulation of Renal Epithelial Tight Junctions by the von Hippel-Lindau Tumor Suppressor Gene Involves Occludin and Claudin 1 and Is Independent of E-Cadherin
Mol. Biol. Cell, February 1, 2009; 20(3): 1089 - 1101.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
W. Zheng, J. Kuhlicke, K. Jackel, H. K. Eltzschig, A. Singh, M. Sjoblom, B. Riederer, C. Weinhold, U. Seidler, S. P. Colgan, et al.
Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium
FASEB J, January 1, 2009; 23(1): 204 - 213.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. L. Semenza
Does Loss of CD151 Expression Promote the Metastasis of Hypoxic Colon Cancer Cells?
Clin. Cancer Res., December 15, 2008; 14(24): 7969 - 7970.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Feijoo-Cuaresma, F. Mendez, A. Maqueda, M. A. Esteban, S. Naranjo-Suarez, M. C. Castellanos, M. H. del Cerro, S. N. Vazquez, A. Garcia-Pardo, M. O. Landazuri, et al.
Inadequate Activation of the GTPase RhoA Contributes to the Lack of Fibronectin Matrix Assembly in von Hippel-Lindau Protein-defective Renal Cancer Cells
J. Biol. Chem., September 5, 2008; 283(36): 24982 - 24990.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
I. J. Frew and W. Krek
pVHL: A Multipurpose Adaptor Protein
Sci. Signal., June 17, 2008; 1(24): pe30 - pe30.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. Beltran, I. Puig, C. Pena, J. M. Garcia, A. B. Alvarez, R. Pena, F. Bonilla, and A. G. de Herreros
A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition
Genes & Dev., March 15, 2008; 22(6): 756 - 769.
[Abstract] [Full Text] [PDF]

Home page
 Am Soc Clin Oncol Ed BookHome page
G. L. Semenza
Hypoxia-inducible Factor 1 and Human Cancer
ASCO Educational Book, January 1, 2008; 2008(1): 548 - 551.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Scheel, T. Onder, A. Karnoub, R. A. Weinberg, and J. E. Talmadge
Adaptation versus Selection: The Origins of Metastatic Behavior
Cancer Res., December 15, 2007; 67(24): 11476 - 11480.
[Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
X. Xia, T. Rasmussen, X. Alvarez, T. Taguchi, M. Li, and V. F. La Russa
Fluorescence In Situ Hybridization Using an Old World Monkey Y Chromosome specific Probe Combined With Immunofluorescence Staining on Rhesus Monkey Tissues
J. Histochem. Cytochem., November 1, 2007; 55(11): 1115 - 1121.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J.-w. Kim, P. Gao, Y.-C. Liu, G. L. Semenza, and C. V. Dang
Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1
Mol. Cell. Biol., November 1, 2007; 27(21): 7381 - 7393.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J. Mejlvang, M. Kriajevska, C. Vandewalle, T. Chernova, A. E. Sayan, G. Berx, J. K. Mellon, and E. Tulchinsky
Direct Repression of Cyclin D1 by SIP1 Attenuates Cell Cycle Progression in Cells Undergoing an Epithelial Mesenchymal Transition
Mol. Biol. Cell, November 1, 2007; 18(11): 4615 - 4624.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
F. Wang, C. Sloss, X. Zhang, S. W. Lee, and J. C. Cusack
Membrane-Bound Heparin-Binding Epidermal Growth Factor Like Growth Factor Regulates E-Cadherin Expression in Pancreatic Carcinoma Cells
Cancer Res., September 15, 2007; 67(18): 8486 - 8493.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L. Li, L. Zhang, X. Zhang, Q. Yan, Y. A. Minamishima, A. F. Olumi, M. Mao, S. Bartz, and W. G. Kaelin Jr.
Hypoxia-Inducible Factor Linked to Differential Kidney Cancer Risk Seen with Type 2A and Type 2B VHL Mutations
Mol. Cell. Biol., August 1, 2007; 27(15): 5381 - 5392.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
R. D. Lester, M. Jo, V. Montel, S. Takimoto, and S. L. Gonias
uPAR induces epithelial mesenchymal transition in hypoxic breast cancer cells
J. Cell Biol., July 24, 2007; 178(3): 425 - 436.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
W. G. Kaelin Jr.
The von Hippel-Lindau Tumor Suppressor Protein and Clear Cell Renal Carcinoma
Clin. Cancer Res., January 15, 2007; 13(2): 680s - 684s.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. J. Evans, R. C. Russell, O. Roche, T. N. Burry, J. E. Fish, V. W. K. Chow, W. Y. Kim, A. Saravanan, M. A. Maynard, M. L. Gervais, et al.
VHL Promotes E2 Box-Dependent E-Cadherin Transcription by HIF-Mediated Regulation of SIP1 and Snail
Mol. Cell. Biol., January 1, 2007; 27(1): 157 - 169.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
G. L. Semenza
Baffled by Bafilomycin: An Anticancer Agent That Induces Hypoxia-Inducible Factor-1{alpha} Expression
Mol. Pharmacol., December 1, 2006; 70(6): 1841 - 1843.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Q. Zhang, S.-Y. Wang, A. C. Nottke, J. V. Rocheleau, D. W. Piston, and R. H. Goodman
Redox sensor CtBP mediates hypoxia-induced tumor cell migration
PNAS, June 13, 2006; 103(24): 9029 - 9033.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
J. A. Garcia
HIFing the Brakes: Therapeutic Opportunities for Treatment of Human Malignancies
Sci. Signal., May 30, 2006; 2006(337): pe25 - pe25.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Melillo and G. L. Semenza
Meeting Report: Exploiting the Tumor Microenvironment for Therapeutics.
Cancer Res., May 1, 2006; 66(9): 4558 - 4560.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2006 by the American Association for Cancer Research.