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[Cancer Research 66, 3963-3966, April 15, 2006]
© 2006 American Association for Cancer Research

Reviews

Akt Signaling and Cancer: Surviving but not Moving On

Alex Toker and Merav Yoeli-Lerner

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston

Requests for reprints: Alex Toker, Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, RN-237, Boston, MA 02215. Phone: 617-667-8535; Fax: 617-667-3616; E-mail: atoker{at}bidmc.harvard.edu.

The frequent deregulation of the phosphoinositide 3-kinase/Akt survival signaling pathway in cancer has prompted significant interest in blocking this pathway to treat cancer. Recently, however, two studies have shown that the Akt isoform Akt1 limits the invasive migration of breast cancer cells. These studies suggest that Akt1 may have a dual role in tumorigenesis, acting not only pro-oncogenically by suppressing apoptosis but also anti-oncogenically by suppressing invasion and metastasis. We discuss the possible implications of these findings for therapeutic development of Akt inhibitors to treat cancer. (Cancer Res 2006; 66(8): 3963-6)




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Copyright © 2006 by the American Association for Cancer Research.