Cancer Research Infection and Cancer: Biology, Therapeutics, and Prevention AACR Conference on Molecular Diagnostics - 2008
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Data
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ding, L.
Right arrow Articles by Kleer, C. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ding, L.
Right arrow Articles by Kleer, C. G.
[Cancer Research 66, 4095-4099, April 15, 2006]
© 2006 American Association for Cancer Research

Molecular Biology, Pathobiology, and Genetics

Identification of EZH2 as a Molecular Marker for a Precancerous State in Morphologically Normal Breast Tissues

Lei Ding1,3, Christine Erdmann3,4, Arul M. Chinnaiyan1,3, Sofia D. Merajver2,3 and Celina G. Kleer1,3

Departments of 1 Pathology and 2 Internal Medicine, 3 the Comprehensive Cancer Center, University of Michigan Medical School; and 4 Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan

Requests for reprints: Celina G. Kleer, Department of Pathology, University of Michigan, 3510C MSRB1, 1150 West, Medical Center Drive, Ann Arbor, MI 48109. Phone: 734-615-3448; Fax: 734-615-3441; E-mail: kleer{at}umich.edu.

The discovery of molecular markers to detect the precancerous state would have profound implications in the prevention of breast cancer. We report that the expression of the Polycomb group protein EZH2 increases in histologically normal breast epithelium with higher risk of developing cancer. We identify EZH2 as a potential marker for detecting preneoplastic lesions of the breast in vivo and as a possible target for preventative intervention. (Cancer Res 2006; 66(8): 4095-9)




This article has been cited by other articles:


Home page
 Stem CellsHome page
V. K. Rajasekhar and M. Begemann
Concise Review: Roles of Polycomb Group Proteins in Development and Disease: A Stem Cell Perspective
Stem Cells, October 1, 2007; 25(10): 2498 - 2510.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
A. Miremadi, M. Z. Oestergaard, P. D.P. Pharoah, and C. Caldas
Cancer genetics of epigenetic genes
Hum. Mol. Genet., April 15, 2007; 16(R1): R28 - R49.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Rauch, Z. Wang, X. Zhang, X. Zhong, X. Wu, S. K. Lau, K. H. Kernstine, A. D. Riggs, and G. P. Pfeifer
Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay
PNAS, March 27, 2007; 104(13): 5527 - 5532.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. J. Kee, J.-R. Kim, K.-I. Nam, H. Y. Park, S. Shin, J. C. Kim, Y. Shimono, M. Takahashi, M. H. Jeong, N. Kim, et al.
Enhancer of Polycomb1, a Novel Homeodomain Only Protein-binding Partner, Induces Skeletal Muscle Differentiation
J. Biol. Chem., March 9, 2007; 282(10): 7700 - 7709.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Ding and C. G. Kleer
Enhancer of Zeste 2 as a Marker of Preneoplastic Progression in the Breast
Cancer Res., October 1, 2006; 66(19): 9352 - 9355.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Rauch, H. Li, X. Wu, and G. P. Pfeifer
MIRA-Assisted Microarray Analysis, a New Technology for the Determination of DNA Methylation Patterns, Identifies Frequent Methylation of Homeodomain-Containing Genes in Lung Cancer Cells
Cancer Res., August 15, 2006; 66(16): 7939 - 7947.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2006 by the American Association for Cancer Research.