Cancer Research AACR Conference on Molecular Diagnostics - 2008 Translational Medicine Conference in Israel
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yang, J.
Right arrow Articles by Weinberg, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yang, J.
Right arrow Articles by Weinberg, R. A.
Related Collections
Right arrow Tumor Biology
Right arrow Tumor Biology: Invasion and Metastasis
[Cancer Research 66, 4549-4552, May 1, 2006]
© 2006 American Association for Cancer Research

Reviews

Exploring a New Twist on Tumor Metastasis

Jing Yang1, Sendurai A. Mani1 and Robert A. Weinberg1,2

1 Whitehead Institute for Biomedical Research, Cambridge Center and 2 Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts

Requests for reprints: Robert A. Weinberg, Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02142. Phone: 617-258-5176; E-mail: weinberg{at}wi.mit.edu.

Unraveling the genetic programs that drive -metastasis may offer insights into how to limit or prevent this deadly aspect of cancer progression. Our recent studies indicate that tumor cell metastasis involves the activity of the transcription factor, Twist, which regulates epithelial-mesenchymal transition and early embryonic morphogenesis. Here, we review the Twist signaling pathway during normal development and discuss how the transcription factor Twist and the epithelial-mesenchymal transition program impinge their biological functions during tumor metastasis. (Cancer Res 2006; 66(9): 4549-52)




This article has been cited by other articles:


Home page
 DevelopmentHome page
C. O. Rodrigues, S. T. Nerlick, E. L. White, J. L. Cleveland, and M. L. King
A Myc-Slug (Snail2)/Twist regulatory circuit directs vascular development
Development, June 1, 2008; 135(11): 1903 - 1911.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Cao, C. Chiarelli, O. Richman, K. Zarrabi, P. Kozarekar, and S. Zucker
Membrane Type 1 Matrix Metalloproteinase Induces Epithelial-to-Mesenchymal Transition in Prostate Cancer
J. Biol. Chem., March 7, 2008; 283(10): 6232 - 6240.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
M. Mimeault and S. K. Batra
Interplay of distinct growth factors during epithelial mesenchymal transition of cancer progenitor cells and molecular targeting as novel cancer therapies
Ann. Onc., October 1, 2007; 18(10): 1605 - 1619.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
B. Hotz, M. Arndt, S. Dullat, S. Bhargava, H.-J. Buhr, and H. G. Hotz
Epithelial to Mesenchymal Transition: Expression of the Regulators Snail, Slug, and Twist in Pancreatic Cancer
Clin. Cancer Res., August 15, 2007; 13(16): 4769 - 4776.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
J. T. Do, D. W. Han, L. Gentile, I. Sobek-Klocke, M. Stehling, H. T. Lee, and H. R. Scholer
Erasure of Cellular Memory by Fusion with Pluripotent Cells
Stem Cells, April 1, 2007; 25(4): 1013 - 1020.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
I. J. Fidler
Models for Spontaneous Metastasis
Cancer Res., October 1, 2006; 66(19): 9787 - 9787.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2006 by the American Association for Cancer Research.