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Myc Goes Global: New Tricks for an Old Oncogene

Department of Cell Biology and Human Anatomy, Institute of Pediatric Regenerative Medicine, Shriners Hospital for Children Northern California, University of California Davis School of Medicine, Davis, California

Requests for reprints: Paul S. Knoepfler, Cell Biology and Human Anatomy, University of California Davis, 1 Shields Avenue, 3301 Tupper Hall, Davis, CA 95616. Phone: 916-453-2289; Fax: 916-453-2288; E-mail: knoepfler{at}ucdavis.edu.

Myc, a transcription factor commonly deregulated in tumorigenesis, is thought to mediate its diverse cellular effects by altering the expression of specific target genes. However, it has been difficult to gain a precise understanding of how Myc drives cancer because Myc acts rather weakly at many of its target loci, and it has been reported to regulate as many as 10% to 15% of all cellular genes. A new perspective on this issue has been provided by a recent study that revealed Myc can regulate chromatin structure in a global fashion. These findings suggest actions for Myc that extend beyond the traditional concept of a targeted gene regulator. [Cancer Res 2007;67(11):5061–3]

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