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Tumor-Associated Macrophages Press the Angiogenic Switch in Breast Cancer

¹ Department of Developmental and Molecular Biology, Center of Reproductive Biology and Women's Health and ² Department of Medicine, Oncology Division, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York

Requests for reprints: Jeffrey W. Pollard, DMB, 601 Chanin Building, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461. Phone: 718-430-2090; Fax: 718-430-8663; E-mail: pollard{at}aecom.yu.edu.

The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors. [Cancer Res 2007;67(11):5064–3]

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