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Tumorigenesis in the Brain: Location, Location, Location

¹ Departments of Developmental Neurobiology and Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee and ² Department of Neurology, Washington University School of Medicine, St. Louis, Missouri

Requests for reprints: David H. Gutmann, Department of Neurology, Washington University School of Medicine, Box 8111, 660 South Euclid Avenue, St. Louis, MO 63110. Phone: 314-362-7379; Fax: 314-362-2388; E-mail: gutmannd{at}wustl.edu or Richard J. Gilbertson, Department of Developmental Neurobiology, St Jude Children's Research Hospital, Room 2006G, 332 North Lauderdale Street, Memphis TN 38105. Phone: 901-495-3913; Fax: 901-495-2270; E-mail: Richard.Gilbertson{at}stjude.org.

Emerging evidence from numerous laboratories supports the notion that brain tumors arise from cells with stem cell/neuroglial progenitor cell properties ("cancer stem cells"). Two recent studies suggest that histologically similar tumors from different brain regions are molecularly distinct because they arise from distinct populations of site-restricted progenitor cells. These new findings imply an interaction between the cell of origin, the tumor microenvironment, and specific cancer-causing genetic changes in the evolution of central nervous system tumors. [Cancer Res 2007;67(12):5579–82]