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Cancer Research 67, 8131, September 1, 2007. doi: 10.1158/0008-5472.CAN-06-4493
© 2007 American Association for Cancer Research
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Cell, Tumor, and Stem Cell Biology

Enrichment of a Population of Mammary Gland Cells that Form Mammospheres and Have In vivo Repopulating Activity

Mai-Jing Liao1, Cheng Cheng Zhang1,4, Beiyan Zhou1, Drazen B. Zimonjic3, Sendurai A. Mani1, Megan Kaba1, Ann Gifford1, Ferenc Reinhardt1,2, Nicholas C. Popescu3, Wenjun Guo1, Elinor Ng Eaton1, Harvey F. Lodish1,2 and Robert A. Weinberg1,2

1 Whitehead Institute for Biomedical Research; 2 Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts; 3 Molecular Cytogenetics Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, Maryland; and 4 Departments of Physiology and Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas

Requests for reprints: Robert A. Weinberg, Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142. Phone: 617-258-5159; Fax: 617-258-5213; E-mail: weinberg{at}wi.mit.edu.

The identification of mammary gland stem cells (MGSC) or progenitors is important for the study of normal breast development and tumorigenesis. Based on their immunophenotype, we have isolated a population of mouse mammary gland cells that are capable of forming "mammospheres" in vitro. Importantly, mammospheres are enriched for cells that regenerate an entire mammary gland on implantation into a mammary fat pad. We also undertook cytogenetic analyses of mammosphere-forming cells after prolonged culture, which provided preliminary insight into the genomic stability of these cells. Our identification of new cell surface markers for enriching mammosphere-initiating cells, including endoglin and prion protein, will facilitate the elucidation of the cell biology of MGSC. [Cancer Res 2007;67(17):8131–8]




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2007 by the American Association for Cancer Research.