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A New Central Scaffold for Metastasis: Parsing HEF1/Cas-L/NEDD9

¹ Oncology Research Unit, The Children's Hospital at Westmead, NSW, Australia; ² Discipline of Paediatrics and Child Health, The University of Sydney, NSW, Australia; ³ Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan; and ⁴ Fox Chase Cancer Center, Philadelphia, Pennsylvania

Requests for reprints: Erica A. Golemis, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111. Phone: 215-728-2860; Fax: 215-728-3616; E-mail: EA_Golemis{at}fccc.edu.

Greater understanding of metastasis is required to improve cancer treatment outcomes. Recently, changes in expression of the scaffold protein HEF1/CAS-L/NEDD9 were found to be a potent prometastatic stimulus in melanoma and other cancers. Mechanistic studies suggest diverse cellular roles of HEF1 and highlight its importance in the response to extracellular cues that drive invasion and metastasis. As a metastatic "hub" for signaling in cancer, HEF1 may provide a useful target for drug discovery efforts. [Cancer Res 2007;67(19):8975–9]

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