Cancer Research Cancer Medicine 8  EMT and Cancer Progression and Treatment
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Cancer Research 67, 10207, November 1, 2007. doi: 10.1158/0008-5472.CAN-07-2574
© 2007 American Association for Cancer Research

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Molecular Biology, Pathobiology, and Genetics

Degradation of Lung Adenoma Susceptibility 1, a Major Candidate Mouse Lung Tumor Modifier, Is Required for Cell Cycle Progression

Yan Liu, Haris G. Vikis, Yijun Yi, Manabu Futamura, Yian Wang and Ming You

Department of Surgery, Washington University School of Medicine, St. Louis, Missouri

Requests for reprints: Ming You, Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University, 660 Euclid Avenue, Box 8109, St. Louis, MO 63110. Phone: 314-362-9294; Fax: 314-362-9366; E-mail: youm{at}wustl.edu.

We have previously identified murine lung adenoma susceptibility 1 (Las1) as the pulmonary adenoma susceptibility 1 candidate gene. Las1 has two natural alleles, Las1-A/J and Las1-B6. Las1 encodes an 85-kDa protein with uncharacterized biological function. In the present study, we report that Las1 is an unstable protein and the rapid destruction of Las1 depends on the ubiquitin-proteasome pathway. Las1 is a new microtubule-binding protein and Las1 associated with tubulin is not ubiquitinated. We further show that Las1-A/J is a more stable protein than Las1-B6. Las1 is expressed in the G2 phase of the cell cycle and that ubiquitin-proteasome–mediated Las1 destruction occurs in mitosis. Overexpression of Las1-A/J inhibits normal E10 cell proliferation and induces a defective cytokinesis. The differential degradation of Las1-A/J and Las-B6 has important implications for its intracellular function and may eventually explain Las1-A/J in lung tumorigenesis. [Cancer Res 2007;67(21):10207–13]




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2007 by the American Association for Cancer Research.