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Integrated Endoplasmic Reticulum Stress Responses in Cancer

¹ Institut National de la Sante et de la Recherche Medicale, E0113; ² Univ Bordeaux 1, Talence, France and ³ Institut National de la Sante et de la Recherche Medicale, U889, Team Avenir; and ⁴ Université Bordeaux 2, Bordeaux, France

Requests for reprints: Eric Chevet, Institut National de la Sante et de la Recherche Medicale, U889, Team Avenir, 33076 Bordeaux, France. E-mail: eric.chevet{at}u-bordeaux2.fr or Michel Moenner, Institut National de la Sante et de la Recherche Medicale, E0113, Talence, France. E-mail: m.moenner{at}angio.u-bordeaux1.fr.

The endoplasmic reticulum (ER) has emerged as a major site of cellular homeostasis regulation, particularly in the unfolded protein response, which is being found to play a major role in cancer and many other diseases. Here, we address ER-mediated signaling and regulations in the context of environmental challenges in cancer, such as hypoxia, angiogenesis, and chemotherapeutic resistance, and we discuss how ER-resident molecular machines become deregulated and involved in cancer-related pathology. Further exploration of how the ER senses, signals, and adapts to stress may redefine and deepen our understanding of its functions in cancer pathobiology. [Cancer Res 2007;67(22):10631–4]

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