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Nuclear Factor-B, an Unappreciated Tumor Suppressor

The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia

Requests for reprints: Fei Chen, The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505. Phone: 304-285-6021; E-mail: fchen{at}cdc.gov.

The notion that nuclear factor-B (NF-B) is a tumor-promoting transcription factor has become a widely accepted dogma in biology. However, recent findings suggest an inhibitory role for NF-B in carcinogenesis and tumorigenesis. Although the tumor suppressor–like effect of NF-B remains to be rigorously established by further studies using cellular and animal models, these latest findings warrant caution with respect to blockage of NF-B activation as a broad strategy in treating cancers. [Cancer Res 2007;67(23):11093–8]

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