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Polo-like Kinase 1 Is Involved in Invasion through Extracellular Matrix

Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California

Requests for reprints: Aylin Rizki, Department of Radiation Oncology, Virginia Commonwealth University, 401 College St., PO Box 980058, Richmond, VA 23298. Phone: 804-628-5534; Fax: 804-827-0635; E-mail: arizki{at}vcu.edu.

Polo-like kinase 1 (PLK1) has important functions in maintaining genome stability via its role in mitosis. Because PLK1 is up-regulated in many invasive carcinomas, we asked whether it may also play a role in acquisition of invasiveness, a crucial step in transition to malignancy. In a model of metaplastic basal-like breast carcinoma progression, we found that PLK1 expression is necessary but not sufficient to induce invasiveness through laminin-rich extracellular matrix. PLK1 mediates invasion via vimentin and β1 integrin, both of which are necessary. We observed that PLK1 phosphorylates vimentin on Ser82, which in turn regulates cell surface levels of β1 integrin. We found PLK1 to be also highly expressed in preinvasive in situ carcinomas of the breast. These results support a role for the involvement of PLK1 in the invasion process and point to this pathway as a potential therapeutic target for preinvasive and invasive breast carcinoma treatment. [Cancer Res 2007;67(23):11106–10]

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