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Identification of Novel Modifier Loci of Apc^Min Affecting Mammary Tumor Development

Departments of ¹ Human Oncology and ² Biostatistics and Medical Informatics, School of Medicine and Public Health and ³ Department of Genetics, University of Wisconsin-Madison, Madison, Wisconsin

Requests for reprints: Amy R. Moser, Department of Human Oncology, University of Wisconsin-Madison, K4/310 CSC Box 3684, 600 Highland Avenue, Madison, WI 53792. Phone: 608-265-6520; Fax: 608-263-9947; E-mail: armoser{at}wisc.edu.

Genetic background affects the susceptibility to mammary tumor development in Apc^Min/+ mice. Here we report the identification of four novel modifier loci that influence different aspects of mammary tumor development in Apc^Min/+ mice. Analysis of tumor development in a backcross of (FVBB6 Apc^Min/+) x B6 Apc^Min/+ mice has identified a modifier on chromosome 9 that significantly affects tumor multiplicity, and a modifier on chromosome 4 that significantly affects tumor latency and affects tumor number with suggestive significance. This modifier was also identified in a backcross involving 129X1/SvJ and B6 Apc^Min/+ mice. A modifier on chromosome 18 specifically affects tumor latency but not tumor number. Kaplan-Meier analysis suggests there is at least an additive interaction affecting tumor latency between the loci on chromosomes 4 and 18. We also identified a modifier locus on chromosome 6 that interacts with the loci on chromosome 4 and chromosome 9 to affect tumor number. These results suggest that multiple genetic loci control different aspects of mammary tumor development. None of these modifiers is associated with intestinal tumor susceptibility, which indicates that these modifiers act on tumor development in a tissue-specific manner. [Cancer Res 2007;67(23):11226–33]