| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Priority Reports |
Divisions of 1 Epigenetics and 2 Molecular Genome Analysis, Deutsches Krebsforschungszentrum; 3 Sektion Translationale Forschung, Thoraxklinik am Universitätsklinikum Heidelberg, Heidelberg, Germany
Requests for reprints: Frank Lyko, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany. Phone: 49-6221-423800; Fax: 49-6221-423802; E-mail: f.lyko{at}dkfz.de.
MicroRNAs (miRNAs) are small noncoding RNAs that repress their target mRNAs by complementary base pairing and induction of the RNA interference pathway. It has been shown that miRNA expression can be regulated by DNA methylation and it has been suggested that altered miRNA gene methylation might contribute to human tumorigenesis. In this study, we show that the human let-7a-3 gene on chromosome 22q13.31 is associated with a CpG island. Let-7a-3 belongs to the archetypal let-7 miRNA gene family and was found to be methylated by the DNA methyltransferases DNMT1 and DNMT3B. The gene was heavily methylated in normal human tissues but hypomethylated in some lung adenocarcinomas. Let-7a-3 hypomethylation facilitated epigenetic reactivation of the gene and elevated expression of let-7a-3 in a human lung cancer cell line resulted in enhanced tumor phenotypes and oncogenic changes in transcription profiles. Our results thus identify let-7a-3 as an epigenetically regulated miRNA gene with oncogenic function and suggest that aberrant miRNA gene methylation might contribute to the human cancer epigenome. [Cancer Res 2007;67(4):141923]
This article has been cited by other articles:
![]() |
B. Boyerinas, S.-M. Park, A. Hau, A. E Murmann, and M. E Peter The role of let-7 in cell differentiation and cancer Endocr. Relat. Cancer, March 1, 2010; 17(1): F19 - F36. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. V. Iorio and C. M. Croce MicroRNAs in Cancer: Small Molecules With a Huge Impact J. Clin. Oncol., December 1, 2009; 27(34): 5848 - 5856. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Sotiropoulou, G. Pampalakis, E. Lianidou, and Z. Mourelatos Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell RNA, August 1, 2009; 15(8): 1443 - 1461. [Abstract] [Full Text] [PDF] |
||||
![]() |
S.P. Barros and S. Offenbacher Epigenetics: Connecting Environment and Genotype to Phenotype and Disease Journal of Dental Research, May 1, 2009; 88(5): 400 - 408. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Roman-Gomez, X. Agirre, A. Jimenez-Velasco, V. Arqueros, A. Vilas-Zornoza, P. Rodriguez-Otero, I. Martin-Subero, L. Garate, L. Cordeu, E. San Jose-Eneriz, et al. Epigenetic Regulation of MicroRNAs in Acute Lymphoblastic Leukemia J. Clin. Oncol., March 10, 2009; 27(8): 1316 - 1322. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Watanabe, Y. Ueda, S.-i. Akaboshi, Y. Hino, Y. Sekita, and M. Nakao HMGA2 Maintains Oncogenic RAS-Induced Epithelial-Mesenchymal Transition in Human Pancreatic Cancer Cells Am. J. Pathol., March 1, 2009; 174(3): 854 - 868. [Abstract] [Full Text] [PDF] |
||||
![]() |
Q. Jiang, Y. Wang, Y. Hao, L. Juan, M. Teng, X. Zhang, M. Li, G. Wang, and Y. Liu miR2Disease: a manually curated database for microRNA deregulation in human disease Nucleic Acids Res., January 1, 2009; 37(suppl_1): D98 - D104. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Yang, S. Kaur, S. Volinia, J. Greshock, H. Lassus, K. Hasegawa, S. Liang, A. Leminen, S. Deng, L. Smith, et al. MicroRNA Microarray Identifies Let-7i as a Novel Biomarker and Therapeutic Target in Human Epithelial Ovarian Cancer Cancer Res., December 15, 2008; 68(24): 10307 - 10314. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. Agirre, A. Jimenez-Velasco, E. San Jose-Eneriz, L. Garate, E. Bandres, L. Cordeu, O. Aparicio, B. Saez, G. Navarro, A. Vilas-Zornoza, et al. Down-Regulation of hsa-miR-10a in Chronic Myeloid Leukemia CD34+ Cells Increases USF2-Mediated Cell Growth Mol. Cancer Res., December 1, 2008; 6(12): 1830 - 1840. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. L. Bearfoot, D. Y.H. Choong, K. L. Gorringe, and I. G. Campbell Genetic Analysis of Cancer-Implicated MicroRNA in Ovarian Cancer Clin. Cancer Res., November 15, 2008; 14(22): 7246 - 7250. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Tokumaru, M. Suzuki, H. Yamada, M. Nagino, and T. Takahashi let-7 regulates Dicer expression and constitutes a negative feedback loop Carcinogenesis, November 1, 2008; 29(11): 2073 - 2077. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Mudhasani, Z. Zhu, G. Hutvagner, C. M. Eischen, S. Lyle, L. L. Hall, J. B. Lawrence, A. N. Imbalzano, and S. N. Jones Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells J. Cell Biol., October 22, 2008; 181(7): 1055 - 1063. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Wu, N. Jolicoeur, Z. Li, L. Zhang, Y. Fortin, D. L'Abbe, Z. Yu, and S.-H. Shen Genetic variations of microRNAs in human cancer and their effects on the expression of miRNAs Carcinogenesis, September 1, 2008; 29(9): 1710 - 1716. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Fazi and C. Nervi MicroRNA: basic mechanisms and transcriptional regulatory networks for cell fate determination Cardiovasc Res, September 1, 2008; 79(4): 553 - 561. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Datta, H. Kutay, M. W. Nasser, G. J. Nuovo, B. Wang, S. Majumder, C.-G. Liu, S. Volinia, C. M. Croce, T. D. Schmittgen, et al. Methylation Mediated Silencing of MicroRNA-1 Gene and Its Role in Hepatocellular Carcinogenesis Cancer Res., July 1, 2008; 68(13): 5049 - 5058. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Nie, M. Gomez, P. Landgraf, J.-F. Garcia, Y. Liu, L. H.C. Tan, A. Chadburn, T. Tuschl, D. M. Knowles, and W. Tam MicroRNA-Mediated Down-Regulation of PRDM1/Blimp-1 in Hodgkin/Reed-Sternberg Cells: A Potential Pathogenetic Lesion in Hodgkin Lymphomas Am. J. Pathol., July 1, 2008; 173(1): 242 - 252. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Toyota, H. Suzuki, Y. Sasaki, R. Maruyama, K. Imai, Y. Shinomura, and T. Tokino Epigenetic Silencing of MicroRNA-34b/c and B-Cell Translocation Gene 4 Is Associated with CpG Island Methylation in Colorectal Cancer Cancer Res., June 1, 2008; 68(11): 4123 - 4132. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Jongen-Lavrencic, S. M. Sun, M. K. Dijkstra, P. J. M. Valk, and B. Lowenberg MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia Blood, May 15, 2008; 111(10): 5078 - 5085. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Hackanson, K. L. Bennett, R. M. Brena, J. Jiang, R. Claus, S.-S. Chen, N. Blagitko-Dorfs, K. Maharry, S. P. Whitman, T. D. Schmittgen, et al. Epigenetic Modification of CCAAT/Enhancer Binding Protein {alpha} Expression in Acute Myeloid Leukemia Cancer Res., May 1, 2008; 68(9): 3142 - 3151. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Esteller Epigenetics in Cancer N. Engl. J. Med., March 13, 2008; 358(11): 1148 - 1159. [Full Text] [PDF] |
||||
![]() |
I. Lee, S. S. Ajay, H. Chen, A. Maruyama, N. Wang, M. G. McInnis, and B. D. Athey Discriminating single-base difference miRNA expressions using microarray Probe Design Guru (ProDeG) Nucleic Acids Res., March 1, 2008; 36(5): e27 - e27. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Lu, D. Katsaros, I. A. Rigault de la Longrais, O. Sochirca, and H. Yu Hypermethylation of let-7a-3 in Epithelial Ovarian Cancer Is Associated with Low Insulin-like Growth Factor-II Expression and Favorable Prognosis Cancer Res., November 1, 2007; 67(21): 10117 - 10122. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. V. Iorio, R. Visone, G. Di Leva, V. Donati, F. Petrocca, P. Casalini, C. Taccioli, S. Volinia, C.-G. Liu, H. Alder, et al. MicroRNA Signatures in Human Ovarian Cancer Cancer Res., September 15, 2007; 67(18): 8699 - 8707. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. D. Johnson, A. Esquela-Kerscher, G. Stefani, M. Byrom, K. Kelnar, D. Ovcharenko, M. Wilson, X. Wang, J. Shelton, J. Shingara, et al. The let-7 MicroRNA Represses Cell Proliferation Pathways in Human Cells Cancer Res., August 15, 2007; 67(16): 7713 - 7722. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Blenkiron and E. A. Miska miRNAs in cancer: approaches, aetiology, diagnostics and therapy Hum. Mol. Genet., April 15, 2007; 16(R1): R106 - R113. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |