Cancer Research 2010 AACR Elections Jordan
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Cancer Research 67, 1419, February 15, 2007. doi: 10.1158/0008-5472.CAN-06-4074
© 2007 American Association for Cancer Research
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Data
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brueckner, B.
Right arrow Articles by Lyko, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brueckner, B.
Right arrow Articles by Lyko, F.

Priority Reports

The Human let-7a-3 Locus Contains an Epigenetically Regulated MicroRNA Gene with Oncogenic Function

Bodo Brueckner1, Carlo Stresemann1, Ruprecht Kuner2, Cora Mund1, Tanja Musch1, Michael Meister3, Holger Sültmann2 and Frank Lyko1

Divisions of 1 Epigenetics and 2 Molecular Genome Analysis, Deutsches Krebsforschungszentrum; 3 Sektion Translationale Forschung, Thoraxklinik am Universitätsklinikum Heidelberg, Heidelberg, Germany

Requests for reprints: Frank Lyko, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany. Phone: 49-6221-423800; Fax: 49-6221-423802; E-mail: f.lyko{at}dkfz.de.

MicroRNAs (miRNAs) are small noncoding RNAs that repress their target mRNAs by complementary base pairing and induction of the RNA interference pathway. It has been shown that miRNA expression can be regulated by DNA methylation and it has been suggested that altered miRNA gene methylation might contribute to human tumorigenesis. In this study, we show that the human let-7a-3 gene on chromosome 22q13.31 is associated with a CpG island. Let-7a-3 belongs to the archetypal let-7 miRNA gene family and was found to be methylated by the DNA methyltransferases DNMT1 and DNMT3B. The gene was heavily methylated in normal human tissues but hypomethylated in some lung adenocarcinomas. Let-7a-3 hypomethylation facilitated epigenetic reactivation of the gene and elevated expression of let-7a-3 in a human lung cancer cell line resulted in enhanced tumor phenotypes and oncogenic changes in transcription profiles. Our results thus identify let-7a-3 as an epigenetically regulated miRNA gene with oncogenic function and suggest that aberrant miRNA gene methylation might contribute to the human cancer epigenome. [Cancer Res 2007;67(4):1419–23]




This article has been cited by other articles:


Home page
 Endocr Relat CancerHome page
B. Boyerinas, S.-M. Park, A. Hau, A. E Murmann, and M. E Peter
The role of let-7 in cell differentiation and cancer
Endocr. Relat. Cancer, March 1, 2010; 17(1): F19 - F36.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. V. Iorio and C. M. Croce
MicroRNAs in Cancer: Small Molecules With a Huge Impact
J. Clin. Oncol., December 1, 2009; 27(34): 5848 - 5856.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
G. Sotiropoulou, G. Pampalakis, E. Lianidou, and Z. Mourelatos
Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell
RNA, August 1, 2009; 15(8): 1443 - 1461.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
S.P. Barros and S. Offenbacher
Epigenetics: Connecting Environment and Genotype to Phenotype and Disease
Journal of Dental Research, May 1, 2009; 88(5): 400 - 408.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. Roman-Gomez, X. Agirre, A. Jimenez-Velasco, V. Arqueros, A. Vilas-Zornoza, P. Rodriguez-Otero, I. Martin-Subero, L. Garate, L. Cordeu, E. San Jose-Eneriz, et al.
Epigenetic Regulation of MicroRNAs in Acute Lymphoblastic Leukemia
J. Clin. Oncol., March 10, 2009; 27(8): 1316 - 1322.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. Watanabe, Y. Ueda, S.-i. Akaboshi, Y. Hino, Y. Sekita, and M. Nakao
HMGA2 Maintains Oncogenic RAS-Induced Epithelial-Mesenchymal Transition in Human Pancreatic Cancer Cells
Am. J. Pathol., March 1, 2009; 174(3): 854 - 868.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
Q. Jiang, Y. Wang, Y. Hao, L. Juan, M. Teng, X. Zhang, M. Li, G. Wang, and Y. Liu
miR2Disease: a manually curated database for microRNA deregulation in human disease
Nucleic Acids Res., January 1, 2009; 37(suppl_1): D98 - D104.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Yang, S. Kaur, S. Volinia, J. Greshock, H. Lassus, K. Hasegawa, S. Liang, A. Leminen, S. Deng, L. Smith, et al.
MicroRNA Microarray Identifies Let-7i as a Novel Biomarker and Therapeutic Target in Human Epithelial Ovarian Cancer
Cancer Res., December 15, 2008; 68(24): 10307 - 10314.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
X. Agirre, A. Jimenez-Velasco, E. San Jose-Eneriz, L. Garate, E. Bandres, L. Cordeu, O. Aparicio, B. Saez, G. Navarro, A. Vilas-Zornoza, et al.
Down-Regulation of hsa-miR-10a in Chronic Myeloid Leukemia CD34+ Cells Increases USF2-Mediated Cell Growth
Mol. Cancer Res., December 1, 2008; 6(12): 1830 - 1840.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. L. Bearfoot, D. Y.H. Choong, K. L. Gorringe, and I. G. Campbell
Genetic Analysis of Cancer-Implicated MicroRNA in Ovarian Cancer
Clin. Cancer Res., November 15, 2008; 14(22): 7246 - 7250.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. Tokumaru, M. Suzuki, H. Yamada, M. Nagino, and T. Takahashi
let-7 regulates Dicer expression and constitutes a negative feedback loop
Carcinogenesis, November 1, 2008; 29(11): 2073 - 2077.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
R. Mudhasani, Z. Zhu, G. Hutvagner, C. M. Eischen, S. Lyle, L. L. Hall, J. B. Lawrence, A. N. Imbalzano, and S. N. Jones
Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells
J. Cell Biol., October 22, 2008; 181(7): 1055 - 1063.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. Wu, N. Jolicoeur, Z. Li, L. Zhang, Y. Fortin, D. L'Abbe, Z. Yu, and S.-H. Shen
Genetic variations of microRNAs in human cancer and their effects on the expression of miRNAs
Carcinogenesis, September 1, 2008; 29(9): 1710 - 1716.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
F. Fazi and C. Nervi
MicroRNA: basic mechanisms and transcriptional regulatory networks for cell fate determination
Cardiovasc Res, September 1, 2008; 79(4): 553 - 561.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Datta, H. Kutay, M. W. Nasser, G. J. Nuovo, B. Wang, S. Majumder, C.-G. Liu, S. Volinia, C. M. Croce, T. D. Schmittgen, et al.
Methylation Mediated Silencing of MicroRNA-1 Gene and Its Role in Hepatocellular Carcinogenesis
Cancer Res., July 1, 2008; 68(13): 5049 - 5058.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. Nie, M. Gomez, P. Landgraf, J.-F. Garcia, Y. Liu, L. H.C. Tan, A. Chadburn, T. Tuschl, D. M. Knowles, and W. Tam
MicroRNA-Mediated Down-Regulation of PRDM1/Blimp-1 in Hodgkin/Reed-Sternberg Cells: A Potential Pathogenetic Lesion in Hodgkin Lymphomas
Am. J. Pathol., July 1, 2008; 173(1): 242 - 252.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Toyota, H. Suzuki, Y. Sasaki, R. Maruyama, K. Imai, Y. Shinomura, and T. Tokino
Epigenetic Silencing of MicroRNA-34b/c and B-Cell Translocation Gene 4 Is Associated with CpG Island Methylation in Colorectal Cancer
Cancer Res., June 1, 2008; 68(11): 4123 - 4132.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Jongen-Lavrencic, S. M. Sun, M. K. Dijkstra, P. J. M. Valk, and B. Lowenberg
MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia
Blood, May 15, 2008; 111(10): 5078 - 5085.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. Hackanson, K. L. Bennett, R. M. Brena, J. Jiang, R. Claus, S.-S. Chen, N. Blagitko-Dorfs, K. Maharry, S. P. Whitman, T. D. Schmittgen, et al.
Epigenetic Modification of CCAAT/Enhancer Binding Protein {alpha} Expression in Acute Myeloid Leukemia
Cancer Res., May 1, 2008; 68(9): 3142 - 3151.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
M. Esteller
Epigenetics in Cancer
N. Engl. J. Med., March 13, 2008; 358(11): 1148 - 1159.
[Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
I. Lee, S. S. Ajay, H. Chen, A. Maruyama, N. Wang, M. G. McInnis, and B. D. Athey
Discriminating single-base difference miRNA expressions using microarray Probe Design Guru (ProDeG)
Nucleic Acids Res., March 1, 2008; 36(5): e27 - e27.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Lu, D. Katsaros, I. A. Rigault de la Longrais, O. Sochirca, and H. Yu
Hypermethylation of let-7a-3 in Epithelial Ovarian Cancer Is Associated with Low Insulin-like Growth Factor-II Expression and Favorable Prognosis
Cancer Res., November 1, 2007; 67(21): 10117 - 10122.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. V. Iorio, R. Visone, G. Di Leva, V. Donati, F. Petrocca, P. Casalini, C. Taccioli, S. Volinia, C.-G. Liu, H. Alder, et al.
MicroRNA Signatures in Human Ovarian Cancer
Cancer Res., September 15, 2007; 67(18): 8699 - 8707.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. D. Johnson, A. Esquela-Kerscher, G. Stefani, M. Byrom, K. Kelnar, D. Ovcharenko, M. Wilson, X. Wang, J. Shelton, J. Shingara, et al.
The let-7 MicroRNA Represses Cell Proliferation Pathways in Human Cells
Cancer Res., August 15, 2007; 67(16): 7713 - 7722.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
C. Blenkiron and E. A. Miska
miRNAs in cancer: approaches, aetiology, diagnostics and therapy
Hum. Mol. Genet., April 15, 2007; 16(R1): R106 - R113.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2007 by the American Association for Cancer Research.