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The Adaptive Immunologic Microenvironment in Colorectal Cancer: A Novel Perspective

¹ Institut National de la Sante et de la Recherche Medicale, UMRS872, Team 13 and Avenir team, Cordeliers Research Center; Université Paris Descartes; Université Pierre et Marie Curie-Paris6; ² AP-HP, European Georges Pompidou Hospital, Department of Immunology, Paris, France

Requests for reprints: Jérôme Galon, Institut National de la Sante et de la Recherche Medicale, UMRS872, Avenir team, Cordeliers Research Center, Paris F-75006, France. E-mail: jerome.galon{at}u255.bhdc.jussieu.fr or Franck Pagès, AP-HP, European Georges Pompidou Hospital, Dept Immunol, Paris F-75015, France. E-mail: franck.pages{at}hop.egp.ap-hop-paris.fr.

Colorectal cancer is one of the most common malignancies, often presenting with a poor prognosis. To date, the anatomic extent of disease has been by far the most important prognostic factor. Recently, we obtained evidence that the type, density, and location of immune cells in colorectal cancer could provide a prognostic factor superior and independent to that of criteria related to the anatomic extent of the tumor. Here, we discuss the meaning and potential implications of this novel finding. [Cancer Res 2007;67(5):1883–6]

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