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Cancer Research 67, 2649, March 15, 2007. doi: 10.1158/0008-5472.CAN-06-1823
© 2007 American Association for Cancer Research
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Cell, Tumor, and Stem Cell Biology

Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors

Jeffrey B. Wyckoff1,2, Yarong Wang2, Elaine Y. Lin3, Jiu-feng Li3, Sumanta Goswami2, E. Richard Stanley3, Jeffrey E. Segall2, Jeffrey W. Pollard3 and John Condeelis1,2

1 Gruss Lipper Center for Biophotonics and Departments of 2 Anatomy and Structural Biology and 3 Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York

Requests for reprints: Jeffrey Wyckoff, Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461. Phone: 718-430-3348; Fax: 718-430-8996; E-mail: jwyckoff{at}aecom.yu.edu.

Although the presence of macrophages in tumors has been correlated with poor prognosis, until now there was no direct observation of how macrophages are involved in hematogenous metastasis. In this study, we use multiphoton microscopy to show, for the first time, that tumor cell intravasation occurs in association with perivascular macrophages in mammary tumors. Furthermore, we show that perivascular macrophages of the mammary tumor are associated with tumor cell intravasation in the absence of local angiogenesis. These results show that the interaction between macrophages and tumor cells lying in close proximity defines a microenvironment that is directly involved in the intravasation of cancer cells in mammary tumors. [Cancer Res 2007;67(6):2649–56]




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Copyright © 2007 by the American Association for Cancer Research.