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Galectin-7 in Lymphoma: Elevated Expression in Human Lymphoid Malignancies and Decreased Lymphoma Dissemination by Antisense Strategies in Experimental Model

¹ INRS-Institut Armand-Frappier, University of Québec, Laval, Québec, Canada; ² Banque de Cellules Leucémiques du Québec, Centre de Recherche Guy-Bernier, Maisonneuve-Rosemont Hospital, Montréal, Québec, Canada; and ³ Centre National de la Recherche Scientifique, UPR 2169, "Instabilité Génétique et Cancer," Institut Gustave-Roussy, Villejuif, France

Requests for reprints: Yves St-Pierre, INRS-Institut Armand-Frappier, University of Québec, 531 Boulevard Des Prairies, Laval, Québec, Canada H7V 1B7. Phone: 450-686-5354; Fax: 450-686-5501; E-mail: yves.st-pierre{at}iaf.inrs.ca.

Galectin-7 is found mainly in stratified squamous epithelia as well as in various other types of cancer cells. As with other members of the galectin family, the expression of galectin-7 has been shown to negatively regulate the development of some tumors while correlating with the progression of other tumor types. For example, up-regulation of galectin-7 is associated with rat mammary carcinomas and with progression to T-cell malignancy. Here, we provide evidence indicating that galectin-7 functions as an important molecule in the dissemination of lymphoma cells in vivo. We found that stable transfection of lymphoma cells with a plasmid encoding antisense galectin-7 cDNA significantly inhibited the dissemination and invasion of lymphoma cells to peripheral organs, thereby increasing the survival of mice. We also found that inhibition of galectin-7 in aggressive lymphoma cells correlated with a decreased invasion of tumor cells in target organs and a reduced expression of matrix metalloproteinase-9, a gene associated with a poor prognosis in non–Hodgkin's lymphoma. We finally examined the expression of galectin-7 in 50 specimens of different mature B-cell neoplasms and found high galectin-7 expression levels in a significant proportion of mature B-cell neoplasms but not in normal B cells. Taken together, these findings suggest that galectin-7 is a potential therapeutic target in the treatment of lymphoid malignancies. [Cancer Res 2007;67(6):2824–9]

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