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Dual Role of Inactivating Lef1 Mutations in Epidermis: Tumor Promotion and Specification of Tumor Type

¹ Cancer Research UK London Research Institute, London, United Kingdom; ² Center for Molecular Medicine Cologne, University of Cologne, Institute of Pathology, Cologne, Germany; and Departments of ³ Dermatology and ⁴ Pathology, Columbia University, College of Physicians and Surgeons, New York, New York

Requests for reprints: Fiona M. Watt, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 ORE, United Kingdom. Phone: 44-12-2340-4400; Fax: 44-12-2340-4199; E-mail: fiona.watt{at}cancer.org.uk.

The NH₂ terminus of LEF1 is frequently mutated in human sebaceous tumors. To investigate how this contributes to cancer, we did two-stage chemical carcinogenesis on K14NLef1 transgenic mice, which express NH₂-terminally truncated Lef1 in the epidermal basal layer. Transgenic mice developed more tumors, more rapidly than littermate controls, even without exposure to tumor promoter. They developed sebaceous tumors, whereas controls developed squamous cell carcinomas. K14NLef1 epidermis failed to up-regulate p53 and p21 proteins during tumorigenesis or in response to UV irradiation, and this correlated with impaired p14ARF induction. We propose that LEF1 NH₂-terminal mutations play a dual role in skin cancer, specifying tumor type by inhibiting Wnt signaling and acting as a tumor promoter by preventing induction of p53. [Cancer Res 2007;67(7):2916–21]

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