This Article Full Text Full Text (PDF) All Versions of this Article: 0008-5472.CAN-06-3798v1 67/7/3468    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Thomas-Ahner, J. M. Articles by Oberyszyn, T. M. Search for Related Content PubMed PubMed Citation Articles by Thomas-Ahner, J. M. Articles by Oberyszyn, T. M.

Gender Differences in UVB-Induced Skin Carcinogenesis, Inflammation, and DNA Damage

Departments of ¹ Pathology and ² Veterinary Biosciences, Ohio State University, Columbus, Ohio

Requests for reprints: Tatiana M. Oberyszyn, Ohio State University, 129 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210. Phone: 614-293-9803; Fax: 614-293-9805; E-mail: oberyszyn.1{at}osu.edu.

The American Cancer Society reports the incidence of squamous cell carcinoma in males to be thrice the incidence in females. This increased squamous cell carcinoma incidence has been attributed to men accumulating more sun exposure and using less sun protection than women. To date, there have been no controlled studies examining the effect of gender on skin tumor development following equal doses of UVB. Gender differences in UVB-induced skin carcinogenesis were examined using the Skh-1 mouse model. After chronic exposure to equal doses of UVB, male mice developed tumors earlier and had more tumors than female mice; tumors in male mice tended to be larger, and the total tumor burden was greater than in females. In addition, tumors in males were of more advanced histologic grade compared with those of female mice. To evaluate the contribution of differences in inflammation and DNA damage to differences in skin carcinogenesis, male and female Skh-1 mice were exposed once to 2,240 J/m² UVB and examined 48 h after exposure. Surprisingly, male mice developed less of an inflammatory response, as determined by skin fold thickness and myeloperoxidase activity, compared with females. Interestingly, male mice showed more cutaneous oxidative DNA damage than the females and lower antioxidant levels. These results show a gender bias in skin carcinogenesis and suggest that the gender difference in tumor development is more influenced by the extent of oxidative DNA damage and antioxidant capacities than by inflammatory response. [Cancer Res 2007;67(7):3468–74]

This article has been cited by other articles:

				J. Martin, F. J. Duncan, T. Keiser, S. Shin, D. F. Kusewitt, T. Oberyszyn, A. R. Satoskar, and A. M. VanBuskirk Macrophage migration inhibitory factor (MIF) plays a critical role in pathogenesis of ultraviolet-B (UVB) -induced nonmelanoma skin cancer (NMSC) FASEB J, March 1, 2009; 23(3): 720 - 730. [Abstract] [Full Text] [PDF]

				M. Mancuso, D. Gallo, S. Leonardi, M. Pierdomenico, E. Pasquali, I. De Stefano, S. Rebessi, M. Tanori, G. Scambia, V. Di Majo, et al. Modulation of basal and squamous cell carcinoma by endogenous estrogen in mouse models of skin cancer Carcinogenesis, February 1, 2009; 30(2): 340 - 347. [Abstract] [Full Text] [PDF]

				E. de Vries, T. E. C. Nijsten, O. Visser, E. Bastiaannet, S. van Hattem, M. L. Janssen-Heijnen, and J. -W. W. Coebergh Superior survival of females among 10 538 Dutch melanoma patients is independent of Breslow thickness, histologic type and tumor site Ann. Onc., March 1, 2008; 19(3): 583 - 589. [Abstract] [Full Text] [PDF]

				C. Gebhardt, A. Riehl, M. Durchdewald, J. Nemeth, G. Furstenberger, K. Muller-Decker, A. Enk, B. Arnold, A. Bierhaus, P. P. Nawroth, et al. RAGE signaling sustains inflammation and promotes tumor development J. Exp. Med., February 18, 2008; 205(2): 275 - 285. [Abstract] [Full Text] [PDF]

				P. Talalay, J. W. Fahey, Z. R. Healy, S. L. Wehage, A. L. Benedict, C. Min, and A. T. Dinkova-Kostova Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation PNAS, October 30, 2007; 104(44): 17500 - 17505. [Abstract] [Full Text] [PDF]