Cancer Research Annual Meeting 2010  Sign up for Cancer Research eTOC's
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online

Cancer Research 67, 3989, May 1, 2007. doi: 10.1158/0008-5472.CAN-07-0182
© 2007 American Association for Cancer Research

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Borghesi, L.
Right arrow Articles by Milcarek, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Borghesi, L.
Right arrow Articles by Milcarek, C.
Related Collections
Right arrow Cancer Immunology
Right arrow Cancer Immunology: Innate Immunity
Right arrow Cancer Immunology: Adaptive Immunity

Reviews

Innate versus Adaptive Immunity: A Paradigm Past Its Prime?

Lisa Borghesi and Christine Milcarek

Department of Immunology, University of Pittsburgh Department School of Medicine, Pittsburgh, Pennsylvania

Requests for reprints: Lisa Borghesi, Department of Immunology, University of Pittsburgh Department School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15261. Phone: 412-383-7074; Fax: 412-383-8098; E-mail: borghesi{at}pitt.edu.

Studies in tumor immunology have relied upon the classic paradigm of distinct innate and adaptive parts of the immune system. However, recent advances in immunology suggest that this division may be overly simplistic, with emerging evidence of a breakdown in conventional hallmarks of each system. Here, we provide an overview of this area and discuss how the concept of a continuum of immune cell populations suggests novel areas of investigation in cancer research. [Cancer Res 2007;67(9):3989–93]




This article has been cited by other articles:


Home page
Phil Trans R Soc BHome page
K. Acevedo-Whitehouse and A. L. J. Duffus
Effects of environmental change on wildlife health
Phil Trans R Soc B, November 27, 2009; 364(1534): 3429 - 3438.
[Abstract] [Full Text] [PDF]


Home page
Physiol. GenomicsHome page
G. Rajagopalan, A. Y. Tilahun, Y. W. Asmann, and C. S. David
Early gene expression changes induced by the bacterial superantigen staphylococcal enterotoxin B and its modulation by a proteasome inhibitor
Physiol Genomics, May 13, 2009; 37(3): 279 - 293.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
L. E. Cole, Y. Yang, K. L. Elkins, E. T. Fernandez, N. Qureshi, M. J. Shlomchik, L. A. Herzenberg, L. A. Herzenberg, and S. N. Vogel
Antigen-specific B-1a antibodies induced by Francisella tularensis LPS provide long-term protection against F. tularensis LVS challenge
PNAS, March 17, 2009; 106(11): 4343 - 4348.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
N. Sugimoto, T. Rui, M. Yang, S. Bharwani, O. Handa, N. Yoshida, T. Yoshikawa, and P. R. Kvietys
Points of Control Exerted along the Macrophage-Endothelial Cell-Polymorphonuclear Neutrophil Axis by PECAM-1 in the Innate Immune Response of Acute Colonic Inflammation
J. Immunol., August 1, 2008; 181(3): 2145 - 2154.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
K. Pilbeam, P. Basse, L. Brossay, N. Vujanovic, R. Gerstein, A. N. Vallejo, and L. Borghesi
The Ontogeny and Fate of NK Cells Marked by Permanent DNA Rearrangements
J. Immunol., February 1, 2008; 180(3): 1432 - 1441.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
I. D. Davis, K. Skak, M. J. Smyth, P. E.G. Kristjansen, D. M. Miller, and P. V. Sivakumar
Interleukin-21 Signaling: Functions in Cancer and Autoimmunity
Clin. Cancer Res., December 1, 2007; 13(23): 6926 - 6932.
[Abstract] [Full Text] [PDF]


Home page
Arch Intern MedHome page
H. K. Roy and J. D. Khandekar
Biomarkers for the Early Detection of Cancer: An Inflammatory Concept
Arch Intern Med, September 24, 2007; 167(17): 1822 - 1824.
[Full Text] [PDF]


Home page
CRO ContentHome page
G. C. Prendergast
Biological research in cancer: Convergent versus divergent problems
Cancer Reviews Online Content, June 1, 2007; 2007(3): 5 - 6.
[Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2007 by the American Association for Cancer Research.