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Paradoxes of the EphB4 Receptor in Cancer

¹ Burnham Institute for Medical Research and ² Pathology Department, University of California San Diego, La Jolla, California

Requests for reprints: Elena B. Pasquale, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037. Phone: 858-646-3131; Fax: 858-646-3199; E-mail: elenap{at}burnham.org.

Recent findings have started to uncover the intriguing roles of the Eph family of receptor tyrosine kinases in normal epithelial cells and during oncogenic transformation. This review focuses on EphB4, an Eph receptor that has both tumor-suppressing and tumor-promoting activities in breast cancer. Understanding the multifaceted role of EphB4 in tumorigenesis may allow the development of new anticancer therapies. [Cancer Res 2007;67(9):3994–7]

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