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Cancer Research 68, 106, January 1, 2008. doi: 10.1158/0008-5472.CAN-07-5647
© 2008 American Association for Cancer Research
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Molecular Biology, Pathobiology, and Genetics

Estrogen Induces Repression of the Breast Cancer and Salivary Gland Expression Gene in an Estrogen Receptor {alpha}–Dependent Manner

Nancy Bretschneider1, Heike Brand1, Nicola Miller2, Aoife J. Lowery2, Michael J. Kerin2, Frank Gannon1 and Stefanie Denger1

1 European Molecular Biology Laboratory, Heidelberg, Germany and 2 Department of Surgery, University College Hospital Galway, National University of Ireland, Galway, Ireland

Requests for reprints: Nancy Bretschneider, European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany. Phone: 49-6221-387161; Fax: 49-6221-387518; E-mail: Nancy.Bretschneider{at}embl.de.

The focus of this study is on the expression and regulation of the estrogen-regulated breast cancer and salivary gland expression (BASE) gene that may function as a breast cancer marker. In MCF7 cells, BASE is repressed by estrogen in an estrogen receptor {alpha} (ER{alpha})-dependent manner. Promoter analysis of the BASE gene led to the identification of a 2-kb upstream enhancer that harbors binding sites for ER{alpha} and FoxA1. The recruitment of both ER{alpha} and FoxA1 to this region was shown by chromatin immunoprecipitation analysis. Furthermore, mutation studies and knockdown experiments show a clear separation between gene expression mediated by FoxA1 and ER{alpha}-dependent gene regulation. Additionally, we provide information on BASE expression in human breast tumor samples. [Cancer Res 2008;68(1):106–14]




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2008 by the American Association for Cancer Research.