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Cancer Research 68, 18-21, January 1, 2008. doi: 10.1158/0008-5472.CAN-07-3234
© 2008 American Association for Cancer Research
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Priority Reports

Circulating Colony Stimulating Factor-1 and Breast Cancer Risk

Rulla M. Tamimi1,2, Joan S. Brugge3, Matthew L. Freedman4, Alexander Miron3, J. Dirk Iglehart5, Graham A. Colditz2,6 and Susan E. Hankinson1,2

1 Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; 2 Department of Epidemiology, Harvard School of Public Health; 3 Department of Cell Biology, Harvard Medical School; Departments of 4 Medical Oncology, and 5 Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts; and 6 Department of Surgery, Washington University School of Medicine, St. Louis, Missouri

Requests for reprints: Rulla M. Tamimi, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115. Phone: 617-525-0862; Fax: 617-525-2008; E-mail: rulla.tamimi{at}channing.harvard.edu.

Colony stimulating factor-1 (CSF1) and its receptor (CSF1-R) are important in mammary gland development and have been implicated in breast carcinogenesis. In a nested case-control study in the Nurses' Heath Study of 726 breast cancer cases diagnosed between June 1, 1992, and June 1, 1998, and 734 matched controls, we prospectively evaluated whether circulating levels of CSF1 (assessed in 1989–1990) are associated with breast cancer risk. The association varied by menopausal status (Pheterogeneity = 0.009). CSF1 levels in the highest quartile (versus lowest) were associated with an 85% reduced risk of premenopausal breast cancer [relative risk (RR), 0.15; 95% confidence interval (95% CI), 0.03–0.85; Ptrend = 0.02]. In contrast, CSF1 levels in the highest quartile conferred a 33% increased risk of postmenopausal breast cancer (RR, 1.33; 95% CI, 0.96–1.86; Ptrend = 0.11), with greatest risk for invasive (RR, 1.45; 95% CI, 1.02–2.07; Ptrend = 0.06) and ER+/PR+ tumors (RR, 1.72; 95% CI, 1.11–2.66; Ptrend = 0.04). Thus, the association of circulating CSF1 levels and breast cancer varies by menopausal status. [Cancer Res 2008;68(1):18–21]






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Cancer Research Clinical Cancer Research
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Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2008 by the American Association for Cancer Research.