Cancer Research Translational Cancer Medicine 2008: Cancer Clinical Trials and Personalized Medicine  Susan G. Komen for the Cure-AACR Outstanding Investigator Award for Breast Cancer Research
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Cancer Research 68, 26-33, January 1, 2008. doi: 10.1158/0008-5472.CAN-06-4418
© 2008 American Association for Cancer Research

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Molecular Biology, Pathobiology, and Genetics

Distinctive MicroRNA Profiles Relating to Patient Survival in Esophageal Squamous Cell Carcinoma

Yong Guo1,5,6, Zhaoli Chen3, Liang Zhang5,6, Fang Zhou3, Susheng Shi6, Xiaoli Feng4, Baozhong Li3, Xin Meng5,6, Xi Ma5,6, Mingyong Luo5, Kang Shao3, Ning Li3, Bin Qiu3, Keith Mitchelson1,5,6, Jing Cheng1,2,5,6 and Jie He3

1 Medical Systems Biology Research Center and 2 The State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University; Departments of 3 Thoracic Surgery and 4 Pathology, Cancer Hospital and Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China; and 5 National Engineering Research Center for Beijing Biochip Technology and 6 CapitalBio Corporation, Changping District, Beijing, China

Requests for reprints: Jie He, Department of Thoracic Surgery, Cancer Hospital and Institute, Chinese Academy of Medical Sciences, Beijing 100021, The People's Republic of China. Phone: 86-10-87788863; Fax: 86-10-67713359; E-mail: prof.hejie{at}263.net or Jing Cheng, Medical Systems Biology Research Center, Tsinghua University School of Medicine, Beijing 100084, The People's Republic of China. Phone: 86-10-62772239; Fax: 86-10-62773059; E-mail: jcheng{at}tsinghua.edu.cn.

Esophageal cancer is the sixth leading cause of death from cancer and one of the least studied cancers worldwide. The global microRNA expression profile of esophageal cancer has not been reported previously. Here, for the first time, we have investigated expressed microRNAs in cryopreserved esophageal cancer tissues using advanced microRNA microarray techniques. Our microarray analyses identified seven microRNAs that could distinguish malignant esophageal cancer lesions from adjacent normal tissues. Some microRNAs could be correlated with the different clinicopathologic classifications. High expression of hsa-miR-103/107 correlated with poor survival by univariate analysis as well as by multivariate analysis. These results indicate that microRNA expression profiles are important diagnostic and prognostic markers of esophageal cancer, which might be analyzed simply using economical approaches such as reverse transcription-PCR. [Cancer Res 2008;68(1):26–33]







HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
Copyright © 2008 by the American Association for Cancer Research.