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Distinctive MicroRNA Profiles Relating to Patient Survival in Esophageal Squamous Cell Carcinoma

¹ Medical Systems Biology Research Center and ² The State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University; Departments of ³ Thoracic Surgery and ⁴ Pathology, Cancer Hospital and Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China; and ⁵ National Engineering Research Center for Beijing Biochip Technology and ⁶ CapitalBio Corporation, Changping District, Beijing, China

Requests for reprints: Jie He, Department of Thoracic Surgery, Cancer Hospital and Institute, Chinese Academy of Medical Sciences, Beijing 100021, The People's Republic of China. Phone: 86-10-87788863; Fax: 86-10-67713359; E-mail: prof.hejie{at}263.net or Jing Cheng, Medical Systems Biology Research Center, Tsinghua University School of Medicine, Beijing 100084, The People's Republic of China. Phone: 86-10-62772239; Fax: 86-10-62773059; E-mail: jcheng{at}tsinghua.edu.cn.

Esophageal cancer is the sixth leading cause of death from cancer and one of the least studied cancers worldwide. The global microRNA expression profile of esophageal cancer has not been reported previously. Here, for the first time, we have investigated expressed microRNAs in cryopreserved esophageal cancer tissues using advanced microRNA microarray techniques. Our microarray analyses identified seven microRNAs that could distinguish malignant esophageal cancer lesions from adjacent normal tissues. Some microRNAs could be correlated with the different clinicopathologic classifications. High expression of hsa-miR-103/107 correlated with poor survival by univariate analysis as well as by multivariate analysis. These results indicate that microRNA expression profiles are important diagnostic and prognostic markers of esophageal cancer, which might be analyzed simply using economical approaches such as reverse transcription-PCR. [Cancer Res 2008;68(1):26–33]

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