| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Priority Reports |
1 Division of Neuro-Oncology, Neurology Department, University of Virginia Health System, Charlottesville, Virginia; 2 Dardinger Laboratory for Neuro-Oncology and Neurosciences, Department of Neurological Surgery, Ohio State University Medical Center, Columbus, Ohio; and 3 Neuro-Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland
Requests for reprints: Benjamin Purow, University of Virginia Neuro-Oncology Center, Box 800434, Hospital West Complex 6th Floor, Charlottesville, VA 22908. Phone: 434-924-5545; Fax: 434-243-6843; E-mail: bwp5g{at}virginia.edu.
Key Words: microRNA • EGFR • Akt • glioblastoma • microRNA-7
microRNAs are noncoding RNAs inhibiting expression of numerous target genes, and a few have been shown to act as oncogenes or tumor suppressors. We show that microRNA-7 (miR-7) is a potential tumor suppressor in glioblastoma targeting critical cancer pathways. miR-7 potently suppressed epidermal growth factor receptor expression, and furthermore it independently inhibited the Akt pathway via targeting upstream regulators. miR-7 expression was down-regulated in glioblastoma versus surrounding brain, with a mechanism involving impaired processing. Importantly, transfection with miR-7 decreased viability and invasiveness of primary glioblastoma lines. This study establishes miR-7 as a regulator of major cancer pathways and suggests that it has therapeutic potential for glioblastoma. [Cancer Res 2008;68(10):3566–71]
This article has been cited by other articles:
|
|
 |
|
  J. T. Huse, C. Brennan, D. Hambardzumyan, B. Wee, J. Pena, S. H. Rouhanifard, C. Sohn-Lee, C. le Sage, R. Agami, T. Tuschl, et al. The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo Genes & Dev., June 1, 2009; 23(11): 1327 - 1337. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-C. Pignon, B. Koopmansch, G. Nolens, L. Delacroix, D. Waltregny, and R. Winkler Androgen Receptor Controls EGFR and ERBB2 Gene Expression at Different Levels in Prostate Cancer Cell Lines Cancer Res., April 1, 2009; 69(7): 2941 - 2949. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Duex and A. Sorkin RNA Interference Screen Identifies Usp18 as a Regulator of Epidermal Growth Factor Receptor Synthesis Mol. Biol. Cell, March 15, 2009; 20(6): 1833 - 1844. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Webster, K. M. Giles, K. J. Price, P. M. Zhang, J. S. Mattick, and P. J. Leedman Regulation of Epidermal Growth Factor Receptor Signaling in Human Cancer Cells by MicroRNA-7 J. Biol. Chem., February 27, 2009; 284(9): 5731 - 5741. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zeng Regulation of the Mammalian Nervous System by MicroRNAs Mol. Pharmacol., February 1, 2009; 75(2): 259 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Nelson and G. J. Weiss MicroRNAs and cancer: past, present, and potential future Mol. Cancer Ther., December 1, 2008; 7(12): 3655 - 3660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. N. Reddy, K. Ohshiro, S. K. Rayala, and R. Kumar MicroRNA-7, a Homeobox D10 Target, Inhibits p21-Activated Kinase 1 and Regulates Its Functions Cancer Res., October 15, 2008; 68(20): 8195 - 8200. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
