This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Coffelt, S. B. Articles by Scandurro, A. B. Search for Related Content PubMed PubMed Citation Articles by Coffelt, S. B. Articles by Scandurro, A. B. Related Collections Tumor Biology Tumor Biology: Inflammation and Immune Escape Cancer Immunology Cancer Immunology: Innate Immunity

Tumors Sound the Alarmin(s)

Department of Microbiology and Immunology, Tulane University, New Orleans, Louisiana

Requests for reprints: Aline B. Scandurro, 1430 Tulane Avenue SL-38, New Orleans, LA 70112. Phone: 504-988-1934; Fax: 504-988-5144; E-mail: alibscan{at}tulane.edu.

Key Words: defensin • cathelicidin • hCAP-18 • LL-37 • HMGB1 • alarmin • danger signal • TLR

Recent evidence suggests that inflammatory molecules play critical roles in the development and progression of numerous tumors. However, one specific group of inflammatory molecules whose importance has been established in host immune responses, termed alarmins, has been largely overlooked in cancer biology. The function of several alarmins—including the defensins, LL-37, and HMGB1—in tumor development, progression, or suppression is discussed here. Taken together, these studies indicate that alarmins represent potential new targets for manipulation in a variety of tumors. [Cancer Res 2008;68(16):6482–5]

This article has been cited by other articles:

				L. Campana, L. Bosurgi, M. E. Bianchi, A. A. Manfredi, and P. Rovere-Querini Requirement of HMGB1 for stromal cell-derived factor-1/CXCL12-dependent migration of macrophages and dendritic cells J. Leukoc. Biol., September 1, 2009; 86(3): 609 - 615. [Abstract] [Full Text] [PDF]

				E. White and R. S. DiPaola The Double-Edged Sword of Autophagy Modulation in Cancer Clin. Cancer Res., September 1, 2009; 15(17): 5308 - 5316. [Abstract] [Full Text] [PDF]

				S. B. Coffelt, S. L. Tomchuck, K. J. Zwezdaryk, E. S. Danka, and A. B. Scandurro Leucine Leucine-37 Uses Formyl Peptide Receptor-Like 1 to Activate Signal Transduction Pathways, Stimulate Oncogenic Gene Expression, and Enhance the Invasiveness of Ovarian Cancer Cells Mol. Cancer Res., June 1, 2009; 7(6): 907 - 915. [Abstract] [Full Text] [PDF]

				S. B. Coffelt, F. C. Marini, K. Watson, K. J. Zwezdaryk, J. L. Dembinski, H. L. LaMarca, S. L. Tomchuck, K. H. zu Bentrup, E. S. Danka, S. L. Henkle, et al. The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells PNAS, March 10, 2009; 106(10): 3806 - 3811. [Abstract] [Full Text] [PDF]

				G. C. Prendergast Inflammatory mediators in cancer etiology and targets for therapy and prevention Cancer Reviews Online Content, September 1, 2008; 2008(9): 17 - 18. [Full Text] [PDF]